中山大學謝志課題組接受生物信息學方向碩士研究生
中山大學謝志課題組主要從事基於生物信息學和高通量測序的系統生物學研究,主要研究方向為:(1)基因表達調控; (2)開發高通量測序分析工具及資料庫;(3)利用深度學習挖掘生物醫學大數據。目前實驗室擁有高通量測序儀(Hiseq2500和Miseq)、設備完善的分子生物學實驗室和浮點運算10萬億次的高性能計算集群,新投入1000萬元的高性能集群即將開始使用。乾濕結合的實驗平臺為高水平交叉學科研究提供了有力保障。實驗室研究經費充足,鼓勵研究創新。實驗室主頁:sysbio.gzzoc.com。
謝志,中山大學眼科中心及眼科學國家重點實驗室教授、兼任中山大學生物醫學大數據中心主任、廣東省生物信息學會理事長。回國前任美國國家癌症研究院研究員(Investigator),2013年入選「千人計劃」青年項目。在《Cell》,《Nature Methods》等國際期刊發表學術論文40篇,代表論文附後。
招收條件:
(1)符合中山大學碩士研究生入學要求。
(2)對生物信息和大數據分析有強烈興趣。
請聯繫:謝志,zhi.xie@outlook.com
代表作:
生物及醫學數據分析工具及資料庫
MECAT: an ultra-fast mapping, error correction, and de novo assembly tool kit for single-molecule sequencing reads, Nature Methods,2017, doi:10.1038/nmeth.4432.(Impact factor: 25.1)
MethSMRT: an integrative database for DNA N6-methyladenine and N4-methylcytosinegenerated by single-molecular real-time sequencing,Nucleic Acids Research,2017,10.1093.gkw950 (Impact factor: 10.2)
Computational resources for ribosome profiling: from database to web server and software. Briefings in Bioinformatics, 2017, 1–12, doi: 10.1093/bib/bbx093. (Impact factor: 8.39)
RPFdb: a database for genome wide information of translated mRNA generated from ribosome profiling.Nucleic Acids Research. 2015 Oct 3. (Impact factor: 10.2)
基因表達轉錄及翻譯調控
Global and cell-type specific properties of lincRNAs with ribosome occupancy,Nucleic Acids Research,2017,10.1093.gkw909 (Impact factor: 10.2)
Ribosome Profiling Reveals Translational Upregulation of Cellular Oxidative Phosphorylation mRNAs During Vaccinia Virus-induced Host Shutoff, Journal of Virology, 2016 Dec 21 (Impact factor: 4.6)
Dynamic landscape of alternative polyadenylation during retinal development,Cellular Molecular Life Science, 2016 Dec 18 (Impact factor: 5.69)
Construction of human activity-based phosphorylation networks.Molecular Systems Biology.2013 09 (Impact factor:11.3)
Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell 139, 610–622. 2009. (Impact factor:31.9)
多組學數據整合分析和數據挖掘
The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes,Cell Reports. 2017 Jan 10;18(2):468-481. doi: 10.1016/j.celrep.2016.12.037 (Impact factor: 8.28)
Integrated transcriptomic and metabolomic analysis reveals adaptive changes of hibernating retinas. J Cell Physiol. 2017 May 25. doi: 10.1002/jcp.26030. (Impact factor: 4.08)
Global analyses of human immune variation reveal baseline predictors of post-vaccination responses. Cell. 2014, 157,499-513 (Impact factor:31.9)