十個中文群:
周一：馮淑豔 河南省人民醫院
周三：李柱一 總群主、唐都醫院
周五：郭 科 湘雅醫院附屬三院
二個英語群:
繼續專題系列講座學習(詳見當日通知)歡迎大家參與。加入英語群方法:請搜索微信號hongquan321或fhxj251
經過多次嘗試，面對眾多的群友，我們病例大討論採取「雙簧」分工模式取得大家的認可，方便了對大家疑問的回答，希望能得到大家更多的建議！
李神經公眾號自2015.9.30運行半年，關注人數已過萬，感謝支持我們的同仁，以及辛苦的老師們，我們將推出更多原創作品及相關學習資料！
為了提高大家的英語學習興趣，我們開設英語群，增加文獻翻譯群，同時上周開啟英語群的新聞總結。這一切為我們實現「雙語同步」奠定了基礎，推動了學習、科研的快速發展！
周一 ：蘭州大學第二醫院 王皓月老師 皓月當空照，病例討論來，頭痛疾患起，治療見奇效。以往的「靜脈竇血栓」病例，大多都是以診斷為主，慢性保守治療，而此病例讓我們看到了「動靜脈聯合，介入藥物並進」的治療方案，效果顯著，讓年輕的媽媽回到了她幸福的家！
（合作病例主持：張旭東）
周三 ： 西安高新醫院 李尊波群主 相信大家都看過《潛伏》，就像孫紅雷一樣，PPS可以潛伏20多年，再次出現新的神經肌肉症狀，表現為原來受累或未受累的肌肉出現新的無力、萎縮、疲勞或疼痛等症狀。真是《萬萬沒想到》！
（合作病例主持：李凱）
周五 ：鄭大一附院 王智軍碩士 發熱妄言頸強直，皮層邊緣腦膜炎，免疫代謝副腫瘤，自身免疫查抗體，GABA別忘記，檢查結果很給力！
（合作病例主持：李建雲）
【英語群回顧】
【2016-5-15 Sunday】Dr. Cheng-jin You Cheng-jinYou led us in discussing the topic of 「Impact ofcerebral white matter changes on functionality in older adults」 by studying the LADIS Study. The LADIS Study is a Europeanmulticenter collaboration that started in 2001 with the support of the EuropeanUnion and was carried out in 11 European centers. A total of 639 participantswere included in the study. Enrolled patients were functionally autonomous,aged 65–84 years, and with WMC on MRI of any degree categorized according to amodified Fazekas scale. The LADISStudy indicated: 1) patients with severe WMC were found to perform significantly worse on global tests ofcognition, executive functions, speed and motor control, attention, naming, andvisuoconstructional praxis in comparison with patients with mild WMC. 2) Whenexamining the location of WMC, deep, rather than periventricular lesions, andthe frontal and temporal locations were strongly associated with depressivesymptoms. On the 3-year follow-up analyses, when the regression model alsoincluded the 「transition to disability」 variable, the severity of WMC significantly predicted GDS scores at 2 years,but not at 3 years. 3) Logistic regression identified frontal deep WMC, but not basal ganglia andinfratentorial hyperintensities, to be significantly associated with balance disturbances. And the LADISresults suggest that regular physical activity might have the potential toreduce the risk of limitations in mobility as a result of WMC.
【2016-5-17 Tuersday】English Forum 2 managerDr. Chen Tao from Department of Neurology, Renmin Hospital, Hubei MedicineUniversity gave us a wonderful lecture with the topic of 「Is Sleep Apnea Affecting my Brain」. Throughthe lecture, we learned that the neurocognitive decline seen in patients withOSAS appears to be a real finding with its own unique pattern of cognitivedeficits. However, the association of OSAS with cognitive impairment iscomplicated by numerous comorbidities, including aging, genetic factors,hypoxemia, EDS, cerebrovascular disease, and endothelial dysfunction. A uniqueclinical syndrome marked by impairment in attention/working memory, vigilance,and executive functioning has been identified. Language and global cognitivefunctioning are relatively spared. Much more work needs to be done to bettertranslate these emerging findings to the clinical setting.
【2016-5-19 Thursday】English Forum 1 CEOHongquan Jiang from No.1 Hos. HMU presented a case of 52-year-old woman withunsteadiness. This patient’s main problem is herincoordination and unsteadiness which has been progressive and chronic. She hasa positive family history which suggests a hereditary etiology. The most likelydiagnosis is one of the spinocerebellar ataxias.
Herprinciple findings on neurological examination are those of incoordination andscanning dysarthria. She has bilateral difficulty with rapid
alternatingmovement, finger to nose, toe to finger and heel to shin. She also has a widestation and ataxia on gait. These findings reflex pancerebellar dysfunction soa disease process that affects the cerebellum or its connections is likely.
Herother finding is hyperreflexia and ankle clonus which suggest bilateralcorticospinal tract or upper motor neuron degeneration. If the patient had hadcerebellar dysfunction without any upper motor neuron dysfunction, then shewould have had hypotonia with pendular reflexes. On plantar reflexes her toesdon’t move either up or down so this finding is inconclusive. The upper motorneuron could be damaged anywhere from its origin to its final destination butwith the cerebellar dysfunction one would look closely at the infratentoriallevel such as in the pons for localization of the lesion.
作者：【主播:劉步、何深文、陳崢 】2016.5.22；編輯：李會琪；