《小喬治的神奇魔藥》中的藥物毒理學分析
作者：
小柯機器人發布時間：2020/12/15 16:00:02
英國皇家德比醫院Graham Johnson團隊對《小喬治的神奇魔藥》中的藥物進行了毒理學分析。2020年12月10日，該研究發表在《英國醫學雜誌》上。
為了分析羅爾德·達爾的書《小喬治的神奇魔藥》中描述的同名藥草的治療效果和毒性，研究組對兩個文學形象，即小喬治和他的姥姥，進行了一項文獻評論。研究組根據國家毒物信息服務的毒物資料庫ToxBase中列出的成分，檢查了每種成分的臨床和毒性作用。
結果發現文中的魔藥含有34種成分。在ToxBase上發現的最常見的毒性作用是噁心和嘔吐（16種成分，佔47％）。潛在威脅生命的影響與13種（38%）成分有關，包括中樞神經系統抑鬱、腎損傷、驚厥、心臟毒性和黏膜侵蝕。書中描述的初始療效是準確的，但後來偏離了最可能的臨床結果（死亡）。
儘管達爾因其《小喬治的神奇魔藥》中藥物成分毒理學的最初準確性而備受讚揚，但總體療效將是致命的、災難性的生理崩潰。應該鼓勵兒童進行科學探索和實驗，在任何人服用之前，必須檢查藥用成分的潛在毒性。
附：英文原文
Title: Toxicological analysis of George’s marvellous medicine: literature review
Author: Graham Johnson, Patrick Davies
Issue&Volume: 2020/12/10
Abstract:
Objective To analyse the therapeutic effects and toxicity of the eponymous concoction described in Roald Dahl’s book George’s Marvellous Medicine.
Design Literature review.
Setting Two literature loving households in England.
Participants George Kranky and grandma Kranky.
Main outcome measures Clinical and toxic effects of the individual ingredients checked against those listed in ToxBase, the National Poisons Information Service’s poisons database.
Results The medicine contained 34 ingredients. The most common toxic effect identified on ToxBase was nausea and vomiting (16 ingredients, 47%). Potentially life threatening effects were associated with 13 (38%) ingredients, including depression of the central nervous system, kidney injury, convulsions, cardiac toxicity, and mucosal erosion. The effects described in the book were accurate initially but then diverted from the most likely clinical outcome (death).
Conclusions Although Dahl ought to be applauded for his initial accuracy about the toxicology of the ingredients in George’s marvellous medicine, the overall effect would be fatal catastrophic physiological collapse. Scientific exploration and experimentation should be encouraged in children, although any medicinal ingredients need to be checked for potential toxicity before being administered—to grandmas or anyone else.
DOI: 10.1136/bmj.m4467
Source: https://www.bmj.com/content/371/bmj.m4467