Job Title: Postdoc Position On The Microenvironmental Control Of Brain Metastasis
The Institute of Neuropathology at the Justus Liebig University in Giessen, Germany, Director Prof. Till Acker, is inviting applications for
1 Postdoc position:
Microenvironmental Control Of BRAIN MetaSTASIS
in the field of tumor biology/neurooncology. The position is available immediately.
Your profile:
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain, a PhD degree. The applicants should possess a strong track record and research background in molecular and cell biology. Experience in cancer research will be an advantage. Preference will be given to applicants with previous experience in one or more of the following areas: hypoxic signalling, functional genomics or other high-throughput screening methods, epigenetics or in vivo tumor (brain) metastasis models, advanced microscopy methods, analysis of signalling pathways, proteomic analysis including analysis of posttranslational modifications, protein biochemistry.
Duration of the position: 3 years, with the possibility of extension
Topic:
Regions of low oxygen tension are common findings in malignant tumors, being associated with increased frequency of tumor invasion and metastasis, and thus critically determining the clinical behaviour and outcome of tumors. We work on a broad range of topics, primarily related to the functions of members of the 2-oxoglutarate dependent dioxygenases including the control of oxygen sensing pathways by PHDs, their regulators and downstream effectors such as HIF - in diverse aspects of cancer biology. We are particularly interested in understanding how stress signals from the tumor microenvironment are sensed and integrated to reprogram the metabolic and epigenetic state of the cell in order to promote tumor progression and therapy resistance. The proposed project will aim to dissect the crosstalk between the brain microenvironment and metastasis to understand by which mechanisms tumor cells can metabolically adapt to allow for colonisation of the brain focusing on the control of 2OG dependent dioxygenases.
What we offer:
Our international team offers an open, supportive, dynamic and motivating academic environment with the possibility to work on cutting edge research projects. We have won a number of external research grants and are involved in several national and international collaborative projects. We use a wide spectrum of methods: cloning, cell culture, biochemistry, qRT-PCR, FACS, ELISA, cell-based assays (proliferation, apoptosis, migration, 3D invasion, stem cell isolation and cultivation etc.), shRNA and CRISPR screens, proteomics, transactivation assays, virally-based gene delivery, RNAi and CRISPR silencing, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis, miRNA analyses, DNA methylation array analysis, next generation sequencing, chromatin immunoprecipitation, bioinformatic analysis, animal models and in vivo tumor models as well as access to tumor biopsies.
Application:
Please send your application as a single PDF: cover letter, your CV, certificates of your qualifications, your publication list, recommendation letters from at least two referees and their contact details until 31.05.2019 to Dr. Attila Németh (Attila.Nemeth@patho.med.uni-giessen.de)
Selected references:
Dopeso et al, Cancer Research 2018;78(7):1805-1819.
Depner et al, Nat Commun. 2016;7:12329.
Filatova et al, Cancer Research 2016;76(19):5845-5856.
Henze et al, Nat Commun. 2014;5:5582.
Garvalov et al, Nat Commun. 2014;5:5577.
Sawamiphak et al, Nature 2010; 465(7297):487-91
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