棕色脂肪組織有利於心臟代謝健康

棕色脂肪組織有利於心臟代謝健康

作者：

小柯機器人

發布時間：2021/1/6 16:37:05

美國洛克菲勒大學Paul Cohen小組的研究表明棕色脂肪組織（BAT）與心臟代謝健康有關。2021年1月4日出版的《自然-醫學》發表了這項成果。

研究人員根據有無BAT，對52487名患者的134529例18F-氟脫氧葡萄糖正電子發射計算機斷層掃描術-計算機斷層掃描進行了歸類，並使用傾向評分匹配來組建研究隊列。對研究人群進行掃描的最初目的是尋找與癌症診斷、治療或監測有關的指標，並沒有進行其它刺激。研究發現具有BAT個體心血管疾病的患病率較低，而BAT的存在與2型糖尿病、血脂異常、冠狀動脈疾病、腦血管疾病、充血性心力衰竭和高血壓的低發病率無關。

這些發現為改善血糖、甘油三酸酯和高密度脂蛋白提供了依據。BAT對超重或肥胖個體的益處更為明顯，這表明BAT可能在減輕肥胖弊端中發揮作用。綜上所述，該研究揭示了BAT在促進心臟代謝健康中的潛在作用。

研究人員表示，白色脂肪儲存多餘的能量，而棕色和米色脂肪具有產熱功能，通過消耗能量來產熱。儘管尚不清楚BAT影響人類代謝和心血管疾病的程度，但在小鼠模型中產熱脂肪組織顯著改善了葡萄糖和脂質的體穩態。

附：英文原文

Title: Brown adipose tissue is associated with cardiometabolic health

Author: Tobias Becher, Srikanth Palanisamy, Daniel J. Kramer, Mahmoud Eljalby, Sarah J. Marx, Andreas G. Wibmer, Scott D. Butler, Caroline S. Jiang, Roger Vaughan, Heiko Schder, Allyn Mark, Paul Cohen

Issue&Volume: 2021-01-04

Abstract: White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid homeostasis in mouse models, although the extent to which brown adipose tissue (BAT) influences metabolic and cardiovascular disease in humans is unclear1,2. Here we retrospectively categorized 134,529 18F-fluorodeoxyglucose positron emission tomography–computed tomography scans from 52,487 patients, by presence or absence of BAT, and used propensity score matching to assemble a study cohort. Scans in the study population were initially conducted for indications related to cancer diagnosis, treatment or surveillance, without previous stimulation. We report that individuals with BAT had lower prevalences of cardiometabolic diseases, and the presence of BAT was independently correlated with lower odds of type 2 diabetes, dyslipidemia, coronary artery disease, cerebrovascular disease, congestive heart failure and hypertension. These findings were supported by improved blood glucose, triglyceride and high-density lipoprotein values. The beneficial effects of BAT were more pronounced in individuals with overweight or obesity, indicating that BAT might play a role in mitigating the deleterious effects of obesity. Taken together, our findings highlight a potential role for BAT in promoting cardiometabolic health.

DOI: 10.1038/s41591-020-1126-7

Source: https://www.nature.com/articles/s41591-020-1126-7