2016年3月23日/生物谷BIOON/--電子菸（e-cigarettes）替代菸草香菸的有效性可能取決於它們能否持續提供吸菸者所需的尼古丁量，從而抵制回歸傳統香菸的欲望。
在最新發表於《Addiction》期刊的研究中，研究人員評估了一種測量電子菸尼古丁遞送量的新方法。研究發現，使用"cartomizers（煙彈+霧化器）"的第一代電子菸，在尼古丁遞送方面始終低於使用"atomizers（煙油霧化器）"的後一代電子菸。後一代電子菸能夠蒸發重複性容器中的液體。
煙油霧化器所遞送尼古丁的濃度類似於尼古丁吸入器和菸草香菸，而且在醫用噴霧器的可接受限值內。
"由於電子菸尼古丁遞送的濃度是歐盟菸草產品指令（EU Tobacco Products Directive）的一項要求，我相信這項研究中提出的協議是可行和可靠的，並且能夠用於監管目的"該研究領導作者Konstantinos Farsalinos博士說，"此外，這項研究提供的證據表明，新一代電子菸產品能夠更好地履行職責，可能更有效地替代菸草香菸。"（生物谷Bioon.com）
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DOI: 10.1111/add.13299
Protocol proposal for， and evaluation of， consistency in nicotine delivery from the liquid to the aerosol of electronic cigarettes atomizers： regulatory implications
Aims
To propose a protocol and evaluate the consistency in nicotine delivery to the aerosol of different types of electronic cigarette (EC) atomizers， as required by regulatory authorities.
Design
Three cartomizer and four tank-type atomizer products were tested (three samples per product). The aerosol from three 20-puff sessions from each sample was collected using a smoke machine. Three cartridges from a nicotine inhaler and three tobacco cigarettes were also tested.
Setting
Analytical laboratory in Greece.
Measurements.
Aerosol nicotine levels were measured. Relative standard deviation (RSD， i.e. coefficient of variation) was calculated separately for each cartomizer and replacement atomizer head sample (intrasample RSD) and between different samples (intersample RSD). The percentage difference from the mean， which is used to assess the quality of medicinal nebulizers， was also calculated.
Findings
The aerosol nicotine levels were 1.01-10.61 mg/20 puffs for ECs， 0.12-0.18 mg/20 puffs for the nicotine inhaler and 1.76-2.20 mg/cigarette for the tobacco cigarettes. The intrasample RSDs were 3.7-12.5% for ECs and 14.3% for the nicotine inhaler and 11.1% for the tobacco cigarettes. The intersample RSDs were higher in cartomizers (range： 6.9-37.8%) compared with tank systems (range： 6.4-9.3%). All tank-type atomizers and one cartomizer were within 75-125% of the mean， as dictated for medicinal nebulizers.
Conclusions
Electronic cigarettes that use tank-type atomizers appear to deliver nicotine in more consistent quantities (within the acceptable limits for medicinal nebulizers and similar to the nicotine inhaler) than electronic cigarettes that use cartomizers. The protocol for testing nicotine delivery consistency described in this paper could be used effectively for regulatory purposes.