影片劇情圍繞威爾·特納、伊莉莎白·斯旺、赫克託·巴博沙以及「黑珍珠號」海盜船的一眾船員們試圖營救傑克·斯派洛船長的努力展開，他們還需要與卡特勒·貝克特和戴維·瓊斯為首的東印度貿易公司對抗，挫敗他們永遠消滅所有海盜的野心。
被大章魚吞下去的傑克船長（強尼·戴普 飾）進入了戴維·瓊斯控制的「死界」-世界的盡頭。為了拯救傑克，威爾·特納（奧蘭多·布魯姆 飾）、伊莉莎白（凱拉·奈特莉 飾）和女巫等一行人也來到了「死界」。找到傑克，他們一行人解開迷咒，逃出了世界盡頭。而此時狡猾的卡特勒·貝凱特（湯姆·霍蘭德 飾）已經得到了戴維·瓊斯（比爾·奈伊 飾）的心臟，由此挾持戴維·瓊斯，掌控所有的公海海盜，為東印度公司攫取利益。為了應對危難，各地海盜頭目秘密集會，展開是否釋放女海神，殺掉戴維·瓊斯的爭論。
原來女海神正是戴維·瓊斯的舊情人，兩人之間的微妙關係，成了雙方交鋒的關鍵。在平靜的海面上，風雨降將至，最終的對決即將展開。每個人面臨著怎樣的命運？當最後的審判結束，大海能否重歸往日的寧靜？
At World's End (2007)
Main article: Pirates of the Caribbean: At World's End
Cutler Beckett gains power over Davy Jones, and with the help of Jones' ship, The Flying Dutchman, is now executing his plans to extinguish piracy. To combat the East India Trading Company, the crew of the Black Pearl goes rescuing Jack Sparrow from Davy Jones' Locker, because he is one of the nine pirate lords needed to summon an ancient goddess.
Future
As detailed in The Art of the Pirates of the Caribbean, the proposed story for the fourth film was for Sparrow and Barbossa to meet up in the newly founded New Orleans, before they sail to find the Fountain of Youth together.Johnny Depp signed on to return in September 2008,and Ted Elliott and Terry Rossio began writing under the guidance of producer Jerry Bruckheimer. The film is set for release in 2012.
Geoffrey Rush has expressed interest in returning as Barbossa.Gore Verbinski feels that "the big danger is diminishing the brand [...] it would have to be a tale worthy of telling" for him to return. If the director returned, he noted that "I would start fresh and focus on the further adventures of Captain Jack Sparrow." Unlike the previous films, he will not do it without a complete script. Keira Knightley has stated that she does not wish to continue playing her character of Elizabeth Swann as she wants to do different projects.