歐盟評估維生素B12作為所有動物營養添加劑的安全性

 　　食品夥伴網訊

  2020年12月14日，據歐盟食品安全局（EFSA）消息，應歐盟委員會要求，歐盟動物飼料添加劑和產品（FEEDAP）研究小組就維生素B

₁₂

（vitamin B

₁₂

）作為所有動物營養添加劑的安全性發表科學意見。

 

　　據了解，該維生素B12是由Ensifer adhaerensCNCM‐I 5541生產的。經過評估，專家小組得出結論，該維生素B₁₂對所有動物物種、消費者和環境都是安全的。申請人沒有提供新的證據來促使研究小組重新考慮先前關於用戶安全的結論。部分原文報導如下：

 

　　The vitamin B12 (in the form of cyanocobalamin) under assessment is produced by fermentation with a genetically modified strain of Ensifer adhaerens and it is intended to be used as a nutritional additive for all animal species. In 2018, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) of EFSA issued an opinion on the safety and efficacy of the product. In that assessment, the Panel could not conclude on the safety of the additive for the target species, consumers and the environment due to uncertainties on the safety of the production strain and the resulting product. Due to high endotoxin content, potential inhalation exposure when handling premixtures and reported irritancy for skin and eyes, the additive was considered to pose a risk to user safety. The applicant provided supplementary data on the identity of the production strain, its susceptibility to antibiotics and toxigenic potential, as well as on the absence of cells and recombinant DNA of the production strain in the final product. The production strain is not expected to produce any toxic compound during fermentation but harbours antimicrobial resistance genes. However, viable cells and recombinant DNA of the strain were not detected in the most concentrated form of the additive. With this new information, the FEEDAP Panel concluded that vitamin B12 produced by E. adhaerensCNCM I‐5541 (identified as SCM 2034 in the previous opinion) is safe for all animal species, the consumers and the environment. The applicant did not provide new evidence that would lead the FEEDAP Panel to reconsider previous conclusions regarding the safety for the user.

 

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