患糖尿病的狗的主人更容易發生2型糖尿病
作者:
小柯機器人發布時間:2020/12/17 12:52:45
瑞典烏普薩拉大學Beatrice Kennedy團隊研究了貓狗和主人之間共患糖尿病的風險。2020年12月10日,《英國醫學雜誌》發表了該成果。
為了調查狗和貓的主人及其寵物是否有共患糖尿病的風險,研究組在瑞典進行了一項基於登記的縱向隊列研究。在基準評估期間(2004年1月1日至2006年12月31日)確定了208980對主人-狗對和123566對主人-貓對。主要觀察指標為狗和貓主人的2型糖尿病事件及其寵物的糖尿病事件,包括隨訪期間(2007年1月1日至2012年12月31日)的診斷日期。
狗主人在隨訪期間發生2型糖尿病的風險為每1000人-年7.7例,而貓主人則為每1000人-年7.9例。寵物中糖尿病的發病率為每1000狗-年1.3隻,每1000貓-年2.2隻。糖尿病狗的主人與非糖尿病狗的主人相比,患2型糖尿病的粗風險比為1.38,多變量校正後為1.32。2型糖尿病主人的狗與非2型糖尿病主人的狗相比,患糖尿病的風險增加,粗風險比為1.28,在校正了主人的年齡後風險比降低為1.11。而貓主人為2型糖尿病與貓的糖尿病之間未發現相關性。
研究結果表明,糖尿病狗的主人比非糖尿病狗的主人更容易發生2型糖尿病。
附:英文原文
Title: The shared risk of diabetes between dog and cat owners and their pets: register based cohort study
Author: Rachel Ann Delicano, Ulf Hammar, Agneta Egenvall, Carri Westgarth, Mwenya Mubanga, Liisa Byberg, Tove Fall, Beatrice Kennedy
Issue&Volume: 2020/12/10
Abstract:
Objective To investigate whether dog and cat owners and their pets share a risk of developing diabetes.
Design Cohort study.
Setting Register based longitudinal study, Sweden.
Participants 208980 owner-dog pairs and 123566 owner-cat pairs identified during a baseline assessment period (1 January 2004 to 31 December 2006).
Main outcome measures Type 2 diabetes events in dog and cat owners and diabetes events in their pets, including date of diagnosis during the follow-up period (1 January 2007 to 31 December 2012). Owners with type 2 diabetes were identified by combining information from the National Patient Register, the Cause of Death Register, and the Swedish Prescribed Drug Register. Information on diabetes in the pets was extracted from veterinary care insurance data. Multi-state models were used to assess the hazard ratios with 95% confidence intervals and to adjust for possible shared risk factors, including personal and socioeconomic circumstances.
Results The incidence of type 2 diabetes during follow-up was 7.7 cases per 1000 person years at risk in dog owners and 7.9 cases per 1000 person years at risk in cat owners. The incidence of diabetes in the pets was 1.3 cases per 1000 dog years at risk and 2.2 cases per 1000 cat years at risk. The crude hazard ratio for type 2 diabetes in owners of a dog with diabetes compared with owners of a dog without diabetes was 1.38 (95% confidence interval 1.10 to 1.74), with a multivariable adjusted hazard ratio of 1.32 (1.04 to 1.68). Having an owner with type 2 diabetes was associated with an increased hazard of diabetes in the dog (crude hazard ratio 1.28, 1.01 to 1.63), which was attenuated after adjusting for owner’s age, with the confidence interval crossing the null (1.11, 0.87 to 1.42). No association was found between type 2 diabetes in cat owners and diabetes in their cats (crude hazard ratio 0.99, 0.74 to 1.34, and 1.00, 0.78 to 1.28, respectively).
Conclusions Data indicated that owners of a dog with diabetes were more likely to develop type 2 diabetes during follow-up than owners of a dog without diabetes. It is possible that dogs with diabetes could serve as a sentinel for shared diabetogenic health behaviours and environmental exposures.
DOI: 10.1136/bmj.m4337
Source: https://www.bmj.com/content/371/bmj.m4337