點擊下方，收聽《SCI天天讀》
Prognostic and chemotherapy predictive value of gene expression phenotypes in primary lung adenocarcinoma.
Primary lung adenocarcinoma remains a deadly disease. Gene expressionphenotypes (GEPs) in adenocarcinoma have potential to provide clinically relevantdisease stratification for improved prognosis and treatment prediction, givenappropriate clinical and methodological validation.
Design 2395transcriptional adenocarcinoma profiles were assembled from 17 public cohorts andclassified by a nearest centroid GEP classifier into three subtypes: terminalrespiratory unit (TRU), proximal-proliferative, and proximal-inflammatory, andadditionally scored by five transcriptional metagenes representing differentbiological processes, including proliferation. Prognostic and chemotherapypredictive associations of the subtypes were analyzed by univariate andmultivariate analysis using overall survival or distant metastasis-free survival as endpoints.
Overall, GEPs were associated with patient outcome in both univariate and multivariate analyses, although not in all individual cohorts. Theprognostically relevant division was between TRU and non-TRU classified cases,with expression of proliferation-associated genes as a key prognostic component. In contrast, GEP classification was not predictive of adjuvant chemotherapyresponse. GEP classification showed stability to random perturbations of genes orsamples and alterations to classification procedures (typically <10% of cases percohort switching subtype). High classification variability (>20% of casesswitching subtype) was observed when removing larger or entire fractions of asingle subtype, due to gene-centering shifts not addressable by the classifier.
In a large-scale evaluation we show that GEPs add prognostic value tostandard clinicopathological variables in lung adenocarcinoma. Subject toclassifier refinement and confirmation in prospective cohorts, GEPs havepotential to impact the prognostication of adenocarcinoma patients through amolecularly driven disease stratification.
Prognostic and chemotherapy predictive value of gene expression phenotypes in primary lung adenocarcinoma.
Clinial Cancer Research . 2015 Aug 11. pii: clincanres.0529.2015.
SCI天天讀
「SCI天天讀」是由愛肺云為中國醫生度身製作的電臺節目。「SCI天天讀」精選國際最權威期刊當月的最新文獻摘要，特邀外籍專家進行口播，配合中文播報和文字導讀，每日一篇定時推送，旨在拓展專業同道者的國際眼界，觀摩先進的肺部疾病診療理念和方法，學習原汁原味的美式英語。
有興趣的朋友，可以關注「SCI天天讀」微信公眾號，在內回復即可收聽。
2015胸腺腫瘤WHO分類：
第一部分-總述
第二部分-胸腺瘤
第三部分-混合性胸腺癌
第四部分-其他腫瘤（上）
第五部分-其他腫瘤（下）
第六部分-前景和挑戰
回覆：A01即為第一部分內容，以此類推。
SCI天天讀英文版：
第1期 Rociletinib in EGFR-mutated non-small-cell lung cancer.
第2期 Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.
第3期 A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer.
第4期 Solid Predominant Histologic Subtype in Resected Stage I Lung Adenocarcinoma Isan Independent Predictor of Early, Extrathoracic, Multisite Recurrence and ofPoor Postrecurrence Survival.
第5期 Limited Resection Versus Lobectomy for Older Patients With Early-Stage LungCancer: Impact of Histology.
第6期 Prognostic and chemotherapy predictive value of gene expression phenotypes in primary lung adenocarcinoma.
回覆：E01，即為英文版第1期內容，以此類推。
SCI天天讀中文版：
第1期 Rociletinib治療EGFR突變的非小細胞肺癌
第2期 Rociletinib和多西他賽相比治療進展期鱗形非小細胞肺癌
第3期 支氣管鏡檢查標本的基因表達分類模型分析在肺癌診斷中的應用
回覆：C01，即為中文版第1期內容，以此類推。