仙人掌手!是真是假?Cactus disease (paleo-induced mineral periostitis)

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近日，一例所謂「仙人掌手」的照片在網絡流傳。一時間眾說紛紜，有人認為是真，有人認為是老外的愚人節惡搞。小編於是從著名的radiopaedia.org網站找到原文，請各位自己判斷。後面附有小調查。

原文出處：

標題：Cactus disease (paleo-induced mineral periostitis)

網址：http://radiopaedia.org/cases/cactus-disease-paleo-induced-mineral-periostitis

Cactus disease (paleo-induced mineral periostitis)

Case contributed by  Dr Matt Skalski

Presentation:

Hand pain with areas of skin elevation. History of strict paleo diet for last 18 months.

Patient Data:

Age: 32

Gender: Male

Modality: X-ray

Numerous perpendicular periosteal projections from the phalanges, metacarpals, carpals, and visualized distal radius and ulna, with overlying skin tenting. This appearance is pathognomonic of cactus disease.

Modality: Photo

Clinical photograph

Photograph 1: Cactus disease with multiple areas of skin tenting, a sign only seen in severe disease.Photograph 2 & 3: Hands at the Cuevas de las Manos, Argentina estimated to be 12,000 years old. Several silhouettes demonstrate features of cactus disease supporting its Paleolithic origins. 

Case Discussion:

Paleo-induced mineral periostitis (PiMP) is a recently recognised disease attributed to the so-called 「paleo diet」. It most frequently involves the metacarpals and phalanges producing perpendicular periosteal projections (「spines」), an appearance that has lead to the alternative name of 「cactus disease」. In severe cases the spines can tent the skin and present clinically, although the majority of cases are only detected radiographically after patients complain of hand pain, particularly when squeezing fruits (e.g. crushing goji berries).

Proponents of the paleo diet continue to deny that it causes PiMP, however a strong temporal association and correlation between length of diet and disease severity have proved scientifically robust; 2016 Cochrane Library metareview. Supportive archeological evidence from paleolithic human populations also exists including cave paintings in Argentina showing cactus hands 12,000 years ago (pictured above).

The European Society for Hand Models recently listed the paleo diet as a category 5 risk (alongside wood work, wicket keeping and thumb wrestling) after founding member Spike E. Hanzenfeat announced that his once "really really, ridiculously good looking hands" had been "internally shashlicked" within seven months of commencing the diet. A Broadway adaptation of his story entitled "The Stuff Fools Swallow" is expected in late 2017.

Know Your Risk
Individuals concerned about their dietary risk for cactus disease are advised to complete the PiMP online screening tool.

References

1. Ficknedle AR. Paleo-induced mineral periostitis (PiMP): an old disease new again. J Bone Metab. 2013 Nov;31(6):606-12. - Pubmed citation

2. Kalk TS, Barlow TR, Bow JP. Diet-induced bone disease (Cochrane Review). Cochrane Database Syst Rev. 2016;(1):CD000364 - Pubmed citation

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