Postdoctoral Researcher Position at Ohio State University Comprehensive Cancer Center and College of Medicine
Research Focus:
There is postdoctoral research position opening in the laboratory of Deliang Guo PhD, Director of Center of Cancer Metabolism at The Ohio State University. His laboratory focuses on cancer metabolism, signal transduction, autophagy and miRNA across multiple cancer types, including brain tumors, lung cancer, liver cancer, sarcoma, pancreatic cancer etc. The research also expands to immune-metabolism and collaborate with world-leader in immune-oncology field. His lab was the first to identify EGFR/PI3K signaling upregulates SREBP-1, a membrane-bound transcription factor with a central role in lipid metabolism to control tumor growth (Guo, et al, PNAS, Science Signaling, 2009, Cancer Discovery 2011, Current Pharma Design 2014). Most recently, his lab further unraveled the underlying molecular mechanism linking EGFR/PI3K signaling and glucose to SREBP-1-regulated lipid metabolism. They found that glucose acting as an indispensable activator promotes SREBP signaling pathway via N-glycosylation modification on SCAP protein (Cheng et al., Cancer Cell, 2015). Moreover, they found lipid droplet and miRNA are actively involved in SREBPs regulation and lipid metabolism in malignancies (Geng, et al., Clinical Cancer Research 2016, and Peng et al., Cell Reports 2016, Xiang, et al., Cell Metabolism 2020).
The long-term goal of the research is to understand the underlying molecular mechanisms of how oncogenic signaling regulates metabolism reprogramming to promote tumor growth, and to identify the key molecular targets to treat malignancies. His lab is dedicated to translational research, assessing molecular alterations in cancer patient tissues and obtaining insights from bedside. The laboratory collaborates with outstanding faculty in the newly established Center of Cancer Metabolism and Institute of Immuno-Oncology. There is a high interactive work environment with different aspects in the cancer center. All researchers will get great benefits within the large interactive environment and have great opportunities to interact with many talent investigators and researchers.
Dr. Guo’s research is currently supported by 4 NIH R01s, the American Cancer Society and OSUCCC funds. For additional details on Dr. Guo’s research please visit:http://radiationoncology.osu.edu/research/guolab/index.cfm
Summary of Duties
Perform basic or applied research in tumor metabolism and oncogenic signaling pathway to develop novel therapies for cancer treatment. Identify and select problems to be studied. Learn and use new techniques. Design research, perform experiments, collect and analyze data, writing manuscript. Salary is based on the experience from $48,000-55,000/year in addition to 10% retirement compensation. Health Insurance will be covered by grant as well.
Education/Experience
Doctoral Degree in Ph.D. required; proficient in molecular biology, biochemistry, cancer biology and mice work are required. Previous immune experiences are highly considered.
To be considered for this position please send an updated CV, a brief description of research interests and contact information of three professional references to: deliang.guo@osumc.edu
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