母語潤色案例來源於實際母語潤色工作，均經作者同意或對內容修改後公布。
原文
So far it is still controversial whether these re-differentiated cells can obtain fully functional desired cells even though they can express multiple lineage-specific markers and also appear to represent physiologically relevant cell types, especially for those trans-differentiated cells. Therefore, it is essential to seek an available cellular reservoir to replace lost or damaged neuronal cells to promote functional recovery after CNS injury. Astrocytes are considered to be active components of neuronal circuits in CNS network. Compelling evidence demonstrate that astrocytes can be reprogrammed to convert into NSCs following certain appropriate transcriptional cues and/or inductive signals, and these astrocytes-derived NSCs can re-differentiate to neuronal and glial cells, indicating they acquired multipotency. These findings could provide insights into the use of astrocytes as a prospective candidate for CNS injury and various neurological disorders, but it also raises an important question as to what molecules trigger astrocytes reprogramming to generate NSCs. Accordingly, finding out these signal molecules responsible for directing neural fate conversion of astrocytes into pluripotent NSCs made possible to attain final goal of using these cells as endogenous cell source for in situ neural repair in the CNS without any invasive graft.
分析
這個表達沒錯，但可以更加簡潔、地道一些。
首先，So far後面常常加逗號。
此外，這個句子可以簡化成：It remains controversial whether ...
要表達「產生」的意思，這裡用obtain不太合適（cells obtain cells?），可以將obtain改為give rise to 。
fully functional desired cells修飾成分較多，意思不夠明確，可以拆分並加上必要的介詞：fully functional cells of the desired lineage。
even though前常常加逗號，這樣在句意上可以停頓一下，不會顯得太冗長。
這裡區分一下even though、even if和even when三者之間的關係：
由於中文裡我們常用「能夠」、「可以」等詞，所以在英文裡我們也常常使用can之類的詞語。但是，英文裡的can有時會有「可能」（possibly）的意思，所以對於確切的結果或結論，儘量避免用can，否則會削弱表達的力度。
比如這裡， they can express multiple lineage-specific markers，表達的就是一個既定的事實，所以可以將can去掉。
由於前面的句子較長，這裡可以另起一句：This is particularly true for the trans-differentiated cells.
這個句子裡有三個to，但每個to的作用不一樣。
第一個to引出形式主語的真正主語；第二個to連接seek an available cellular reservoir和replace lost or damaged neuronal cells；第三個to表示目的，可以理解成：為了「promote functional recovery」，「seek an available cellular reservoir to replace lost or damaged neuronal cells」很重要。
為了讓意思更加明確，可以把第三個to改為in order to。
CNS network前應該加上冠詞the。器官、組織、系統前一般都加the。
* 關於醫學論文中冠詞的使用可以參看：英語醫學論文中的冠詞使用。
這裡一般用現在完成時，類似表達還有：studies have shown that ...
前面句子已經夠長了，可以另起一句： These findings suggest that these cells are multipotential.
這句話並無語法錯誤，但可以表達得更加直接一些：Astrocytes could therefore be a prospective candidate for the treatment of CNS injuries and various neurological disorders.
..., but it also raises an important question as to what molecules trigger astrocytes reprogramming to generate NSCs. Accordingly, finding out these signal molecules responsible for directing neural fate conversion of astrocytes into pluripotent NSCs made possible to attain final goal of using these cells as endogenous cell source for in situ neural repair in the CNS without any invasive graft.
在以上句子中，兩處下劃線部分意思重複，可以進行合併，或者將前處刪除。
signal molecules一般為signaling molecules。
made possible to attain final goal of中缺失形式主語和定冠詞，應改為：made it possible to achive the final goal of。
此外，上句中主語太長，表述太繞，其實無非就是要表達「我們要找到這些負責細胞轉化的信號分子，從而相關細胞可以用於神經修復。」
上述文字建議改成以下形式，好處是：1. 文字長度變短；2. 主語變短；3. 句意直接。
However, it will be essential to ascertain which signaling molecules are responsible for directing the neural fate conversion of astrocytes into pluripotent NSCs if these cells are to be used as an endogenous cell source for in situ CNS neural repair without an invasivegraft.
其實這個句子還是比較長，如果有更好的修改建議歡迎留言。
參考修改
It remains controversialwhether these re-differentiated cells can give rise to fully functional cells ofthe desired lineage, even though they express multiple lineage-specific markersand also appear to represent physiologically relevant cell types. This isparticularly true for the trans-differentiated cells. Therefore, it isessential to seek an available cellular reservoir to replace lost or damagedneuronal cells in order to promote functional recovery after CNS injuries.Astrocytes are considered to be active components of neuronal circuits in the CNSnetwork. Compelling evidence has demonstrated that astrocytes can bereprogrammed to convert into NSCs following certain appropriate transcriptionalcues and/or inductive signals, and astrocyte-derived NSCs can then re-differentiateinto neuronal or glial cells. These findings suggest that these cells are multipotential.Astrocytes could therefore be a prospective candidate for the treatment of CNSinjuries and various neurological disorders. However, it will be essential toascertain which signaling molecules are responsible for directing the neuralfate conversion of astrocytes into pluripotent NSCs if these cells are to beused as an endogenous cell source for in situ CNS neural repair without an invasivegraft.
修訂記錄
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