LETTER TO BLOOD| OCTOBER 8, 2020
Impact of TKIs post–allogeneic hematopoietic cell transplantation in Philadelphia chromosome–positive ALLNeeraj Saini, David Marin, Celina Ledesma, Ruby Delgado, Gabriela Rondon, Uday R. Popat, Qaiser Bashir, Chitra M. Hosing, Yago Nieto, Amin M. Alousi, Muzaffar H. Qazilbash, Stefan Ciurea, Elizabeth Shpall, Issa Khouri, Hagop Kantarjian, Elias Jabbour, Farhad Ravandi, Richard E. Champlin, Partow Kebriaei
Blood (2020) 136 (15): 1786–1789.
https://doi.org/10.1182/blood.2019004685
Subjects:
Clinical Trials and Observations, Hematopoiesis and Stem Cells, Lymphoid Neoplasia
TO THE EDITOR:
Tyrosine kinase inhibitors (TKIs) are used post-allogeneic hematopoietic cell transplantation (HCT) to reduce relapse rates in Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL).1,2 However, because results from retrospective studies are conflicting2-9 and there has been no definitive randomized trial,10 the role and duration of maintenance therapy with TKIs post-transplant remain uncertain. Herein, we present updated outcomes of patients with Ph+ ALL who received HCT followed by TKI maintenance at our institution11 and evaluate the impact of TKIs (including newer generations) on survival outcomes in light of available measurable residual disease (MRD), as assessed by quantitative polymerase chain reaction for BCR-ABL1 transcripts at the time of HCT. Furthermore, we attempt to identify the optimal duration of TKI therapy after transplantation.
A total of 171 patients with Ph+ ALL consecutively underwent first HCT...
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