Researchers create lung 'blueprint' that could aid organ regeneration
人造器官將現實，科學家成功繪製人類肺部細胞藍圖
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Serious lung disease has a high rate of mortality, and the only curative treatment is a lung transplant. This is a complicated procedure that has other adverse health effects and oftentimes simply doesn't work, so for scientists in this field, organ regeneration -- that is, growing an organ from the body's own tissue -- is the ultimate solution.
Now, researchers from Yale say they're on track for this very eventuality.
嚴重的肺部疾病死亡率高，唯一的治療方法是肺轉移。這是一個複雜的過程，還會產生其他副作用，並且通常完全不起作用。因此，對於這一領域的科學家來說，器官再生——也就是從人體自身組織中培育出一個器官——是最終的解決方案。
現在，耶魯大學的研究人員表示，他們正在為這種可能性而努力。
Using sophisticated screening processes, the team has created a cellular blueprint of the human lung, making it easier to understand the design of lung function and respiratory diseases. The technology offers an ultrahigh resolution of millions of cells at once.
通過複雜的篩選過程，研究小組繪製除了人類肺部的細胞藍圖，使人們更容易理解肺功能和呼吸系統疾病的設計。這項技術能同時提供 數百萬個細胞的超高解析度。
Professor Naftali Kaminski of the Yale School of Medicine explained that this has only been possible thanks to advances in resolution technology. "It's like we have moved the resolution on cell analysis from looking at the night sky with the naked eye, to a child's telescope, to an observatory and, now, the Hubble telescope," he said.
耶魯大學醫學院的納夫塔利·卡明斯基教授解釋說，這完全歸功於分辨技術的進步。他說「這就像我們把細胞分析的解析度從肉眼觀察夜空的方式，提高到了兒童望遠鏡、天文臺，現在又提高到了哈勃望遠鏡。」
The blueprint will provide researchers with detailed information on the way lung cells interact, and will also help in finding new molecular targets for therapies to treat lung diseases such as pulmonary fibrosis.
該藍圖將為研究人員提供相關肺細胞相互作用方式的詳細信息，海將有助於尋找治療肺疾病（如肺纖維化） 的新分子靶點。
According to the team, there are active bioengineering efforts taking place that aim to grow lung tissue in specially adapted glass jars. The new blueprints will help researchers determine whether or not their lab-grown tissue is on track to become an actual organ, and provide some insight into any changes that need to be made.
據研究小組稱，正在進行積極的生物工程努力，目的是在特製的玻璃瓶中培養肺組織。新的藍圖將幫助研究人員確定他們的實驗室培養的組織是否有望成長為真正的器官，並未需要做出的任何改變提供一些見解。
「We're looking at the basic principles of the development of an organ," Kaminski said. "Applying this approach could allow us to design new organs."
「我們正在研究器官發育的基本原理，」卡明斯基說，「應用這種方法可以讓我們設計出新的器官。」