VISTA是初始T細胞靜止和外周耐受的檢查點調節因子
作者：
小柯機器人發布時間：2020/1/20 10:51:42
美國達特茅斯蓋塞爾醫學院Randolph J. Noelle、Chao Cheng等研究人員合作發現，VISTA是初始T細胞靜止和外周耐受的檢查點調節因子。相關論文發表在2020年1月17日出版的《科學》上。
據研究人員介紹，負檢查點調節因子（NCR）調控T細胞對自身抗原的免疫反應並限制自身免疫的發展。與在活化T淋巴細胞上表達的所有其他NCR不同，在初始T細胞上表達含V型免疫球蛋白結構域的T細胞活化抑制因子（VISTA）。
研究人員報導了小鼠初始的T細胞區室中的異質性，其中VISTA的喪失破壞了主要的靜態初始T細胞亞群並增強了自身反應性。激動性VISTA參與通過促進抗原誘導的外周T細胞缺失而增加了T細胞耐受性。儘管在初始T細胞穩態中起關鍵作用，但在炎症條件下，VISTA抑制初始T細胞反應的能力喪失了。因此，VISTA是初始T細胞的獨特NCR，對於穩定維持靜止狀態和外周耐受至關重要。
附：英文原文
Title: VISTA is a checkpoint regulator for nave T cell quiescence and peripheral tolerance
Author: Mohamed A. ElTanbouly, Yanding Zhao, Elizabeth Nowak, Jiannan Li, Evelien Schaafsma, Isabelle Le Mercier, Sabrina Ceeraz, J. Louise Lines, Changwei Peng, Catherine Carriere, Xin Huang, Maria Day, Brent Koehn, Sam W. Lee, Milagros Silva Morales, Kristin A. Hogquist, Stephen C. Jameson, Daniel Mueller, Jay Rothstein, Bruce R. Blazar, Chao Cheng, Randolph J. Noelle
Issue&Volume: 2020/01/17
Abstract: Negative checkpoint regulators (NCRs) temper the T cell immune response to self-antigens and limit the development of autoimmunity. Unlike all other NCRs that are expressed on activated T lymphocytes, V-type immunoglobulin domain-containing suppressor of T cell activation (VISTA) is expressed on nave T cells. We report an unexpected heterogeneity within the nave T cell compartment in mice, where loss of VISTA disrupted the major quiescent nave T cell subset and enhanced self-reactivity. Agonistic VISTA engagement increased T cell tolerance by promoting antigen-induced peripheral T cell deletion. Although a critical player in nave T cell homeostasis, the ability of VISTA to restrain nave T cell responses was lost under inflammatory conditions. VISTA is therefore a distinctive NCR of nave T cells that is critical for steady-state maintenance of quiescence and peripheral tolerance.
DOI: 10.1126/science.aay0524
Source: https://science.sciencemag.org/content/367/6475/eaay0524
Science：《科學》，創刊於1880年。隸屬於美國科學促進會，最新IF：41.037