西班牙社區居民SARS-CoV-2感染的死亡風險分析
作者：
小柯機器人發布時間：2020/11/30 16:55:32
西班牙卡洛斯三世健康研究所Marina Pollán團隊研究了西班牙社區居民SARS-CoV-2感染的死亡風險。2020年11月27日，該研究發表在《英國醫學雜誌》上。
為了基於covid-19死亡和全因超額死亡來評估SARS-CoV-2感染的致死風險，研究組針對西班牙的covid-19第一波大流行進行了一項全國血清流行病學研究。2020年4月27日至6月22日，西班牙通過全國血清流行病學調查篩查SARS-CoV-2感染，共納入61098位參與者。主要結局為西班牙社區居民中SARS-CoV-2的總體以及特定年齡和性別的感染死亡風險。
Covid-19確診死亡的總感染死亡風險為0.8%，超額死亡風險為1.1%。男性感染死亡風險為1.1％至1.4％不等，女性感染死亡風險為0.6％至0.8％不等。50歲以後，感染致死風險急劇上升，年齡在80歲及以上的男性感染致死風險為11.6％到16.4％不等，80歲及以上女性從4.6％到6.5%不等。
研究結果表明，50歲以後，SARS-CoV-2感染致死風險增大，且男性比女性更明顯。Covid-19的致死率高於其他常見呼吸系統疾病（如季節性流感）。
附：英文原文
Title: Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study
Author: Roberto Pastor-Barriuso, Beatriz Pérez-Gómez, Miguel A Hernán, Mayte Pérez-Olmeda, Raquel Yotti, Jesús Oteo-Iglesias, Jose L Sanmartín, Inmaculada León-Gómez, Aurora Fernández-García, Pablo Fernández-Navarro, Israel Cruz, Mariano Martín, Concepción Delgado-Sanz, Nerea Fernández de Larrea, Jose León Paniagua, Juan F Muoz-Montalvo, Faustino Blanco, Amparo Larrauri, Marina Pollán
Issue&Volume: 2020/11/27
Abstract:
Objective To estimate the infection fatality risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on deaths with confirmed coronavirus disease 2019 (covid-19) and excess deaths from all causes.
Design Nationwide seroepidemiological study.
Setting First wave of covid-19 pandemic in Spain.
Participants Community dwelling individuals of all ages.
Main outcome measures The main outcome measure was overall, and age and sex specific, infection fatality risk for SARS-CoV-2 (the number of covid-19 deaths and excess deaths divided by the estimated number of SARS-CoV-2 infections) in the community dwelling Spanish population. Deaths with laboratory confirmed covid-19 were obtained from the National Epidemiological Surveillance Network (RENAVE) and excess all cause deaths from the Monitoring Mortality System (MoMo), up to 15 July 2020. SARS-CoV-2 infections in Spain were derived from the estimated seroprevalence by a chemiluminescent microparticle immunoassay for IgG antibodies in 61098 participants in the ENE-COVID nationwide seroepidemiological survey between 27 April and 22 June 2020.
Results The overall infection fatality risk was 0.8% (19228 of 2.3 million infected individuals, 95% confidence interval 0.8% to 0.9%) for confirmed covid-19 deaths and 1.1% (24778 of 2.3 million infected individuals, 1.0% to 1.2%) for excess deaths. The infection fatality risk was 1.1% (95% confidence interval 1.0% to 1.2%) to 1.4% (1.3% to 1.5%) in men and 0.6% (0.5% to 0.6%) to 0.8% (0.7% to 0.8%) in women. The infection fatality risk increased sharply after age 50, ranging from 11.6% (8.1% to 16.5%) to 16.4% (11.4% to 23.2%) in men aged 80 or more and from 4.6% (3.4% to 6.3%) to 6.5% (4.7% to 8.8%) in women aged 80 or more.
Conclusion The increase in SARS-CoV-2 infection fatality risk after age 50 appeared to be more noticeable in men than in women. Based on the results of this study, fatality from covid-19 was greater than that reported for other common respiratory diseases, such as seasonal influenza.
DOI: 10.1136/bmj.m4509
Source: https://www.bmj.com/content/371/bmj.m4509