研究揭示人NK細胞發育、功能和駐留的組織決定因素
作者：
小柯機器人發布時間：2020/2/17 10:43:59
近日，美國哥倫比亞大學Donna L. Farber及其小組揭示了人NK細胞發育、功能和駐留的組織決定因素。相關論文2020年2月13日在線發表在《細胞》上。
研究人員探究了組織定位如何調節人類自然殺傷（NK）細胞（這是對抗病毒和腫瘤免疫至關重要的先天淋巴細胞）的發育和功能。整合了來自60名個體的血液、淋巴器官和黏膜組織部位NK細胞的高維分析，研究人員確定了NK細胞亞群的分布、成熟以及不同年齡和個體中功能的組織特異性模式。效應子功能增強的成熟和終末分化NK細胞在血液、骨髓、脾臟和肺中佔主導地位，並在各個部位顯示出共同的轉錄程序。相反，效應子能力降低的前體和未成熟NK細胞遍布淋巴結和腸道，並表現出組織駐留特徵和部位特異性適應性。總之，這些結果揭示了組織駐留群體中NK的細胞發育和維持，而成熟、終末分化的亞群通過不同的外周位點介導免疫監視。
據介紹，不同組織部位的免疫反應對於保護性免疫和體內平衡至關重要。
附：英文原文
Title: Tissue Determinants of Human NK Cell Development, Function, and Residence
Author: Pranay Dogra, Chiara Rancan, Wenji Ma, Marta Toth, Takashi Senda, Dustin J. Carpenter, Masaru Kubota, Rei Matsumoto, Puspa Thapa, Peter A. Szabo, Maya Meimei Li Poon, Jacky Li, Janice Arakawa-Hoyt, Yufeng Shen, Lawrence Fong, Lewis L. Lanier, Donna L. Farber
Issue&Volume: February 13, 2020
Abstract: Immune responses in diverse tissue sites are critical for protective immunity andhomeostasis. Here, we investigate how tissue localization regulates the developmentand function of human natural killer (NK) cells, innate lymphocytes important foranti-viral and tumor immunity. Integrating high-dimensional analysis of NK cells fromblood, lymphoid organs, and mucosal tissue sites from 60 individuals, we identifytissue-specific patterns of NK cell subset distribution, maturation, and functionmaintained across age and between individuals. Mature and terminally differentiatedNK cells with enhanced effector function predominate in blood, bone marrow, spleen,and lungs and exhibit shared transcriptional programs across sites. By contrast, precursorand immature NK cells with reduced effector capacity populate lymph nodes and intestinesand exhibit tissue-resident signatures and site-specific adaptations. Together, ourresults reveal anatomic control of NK cell development and maintenance as tissue-residentpopulations, whereas mature, terminally differentiated subsets mediate immunosurveillancethrough diverse peripheral sites.
DOI: 10.1016/j.cell.2020.01.022
Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30103-3
Cell：《細胞》，創刊於1974年。隸屬於細胞出版社，最新IF：36.216