女性使用永久性染髮劑並不會增加大多數癌症風險和相關死亡率
作者：
小柯機器人發布時間：2020/9/8 21:24:10
美國布列根和婦女醫院和哈佛醫學院Eva S Schernhammer團隊研究了美國女性使用永久性染髮劑與癌症風險和死亡率的關係。2020年9月2日，該研究發表在《英國醫學雜誌》上。
為了探討個人使用永久性染髮劑與癌症風險和死亡率的相關性，研究組進行了一項前瞻性隊列研究，招募了117200名女護士，基線時均沒有癌症，所有參與者都報告個人使用永久性染髮劑的信息，並隨訪36年。
結果發現使用永久性染髮劑的參與者與未使用者相比，患實體癌（共20805例，非黑色素瘤皮膚癌除外）和造血系統癌症的風險均未顯著增加（1807例）。此外,使用染髮劑的參與者特定癌症的風險未顯著增加，包括皮膚鱗狀細胞癌、膀胱癌、黑色素瘤、雌激素受體陽性乳腺癌、孕激素受體陽性乳腺癌、激素受體陽性乳腺癌、腦癌、結腸直腸癌、腎癌、肺癌、以及大多數主要亞類和組織亞型的造血系統癌症，癌症相關死亡風險亦未顯著增加（4860例）。
但使用染色劑的參與者與未使用者相比，基底細胞癌風險略有增加（共22560例，風險比為1.05）。染髮劑累積劑量與雌激素受體陰性乳腺癌、孕激素受體陰性乳腺癌、激素受體陰性乳腺癌和卵巢癌的風險呈正相關。天生深發色的女性中霍奇金淋巴瘤的風險增加，而天生淺發色的女性中基底細胞癌風險較高。
總之，個人使用永久性染髮劑與大多數癌症風險和與癌症相關的死亡率並不相關，但基底細胞癌、乳腺癌（雌激素受體陰性、孕激素受體陰性、激素受體陰性）和卵巢癌的風險有所增加。
附：英文原文
Title: Personal use of permanent hair dyes and cancer risk and mortality in US women: prospective cohort study
Author: Yin Zhang, Brenda M Birmann, Jiali Han, Edward L Giovannucci, Frank E Speizer, Meir J Stampfer, Bernard A Rosner, Eva S Schernhammer
Issue&Volume: 2020/09/02
Abstract: Objective To evaluate the associations between personal use of permanent hair dyes and cancer risk and mortality.
Design Prospective cohort study.
Setting and participants 117200 women enrolled in the Nurses』 Health Study, an ongoing prospective cohort study of female nurses in the United States. The women were free of cancer at baseline, reported information on personal use of permanent hair dyes, and were followed for 36 years.
Exposure Status, duration, frequency, and integral use (cumulative dose calculated from duration and frequency) of permanent hair dyes. Age at first use and time since first use of permanent hair dyes.
Main outcome measures Associations of personal use of permanent hair dyes with risk of overall cancer and specific cancers, and cancer related death. Age and multivariable adjusted hazard ratios and 95% confidence intervals were estimated by using Cox proportional hazard models.
Results Ever users of permanent hair dyes had no significant increases in risk of solid cancers (n=20805, excluding non-melanoma skin cancers; hazard ratio 0.98, 95% confidence interval 0.96 to 1.01) or hematopoietic cancers overall (n=1807; 1.00, 0.91 to 1.10) compared with non-users. Additionally, ever users did not have an increased risk of most specific cancers (cutaneous squamous cell carcinoma, bladder cancer, melanoma, estrogen receptor positive breast cancer, progesterone receptor positive breast cancer, hormone receptor positive breast cancer, brain cancer, colorectal cancer, kidney cancer, lung cancer, and most of the major subclasses and histological subtypes of hematopoietic cancer) or cancer related death (n=4860; 0.96, 0.91 to 1.02). Basal cell carcinoma risk was slightly increased for ever users (n=22560; 1.05, 1.02 to 1.08). Cumulative dose was positively associated with risk of estrogen receptor negative breast cancer, progesterone receptor negative breast cancer, hormone receptor negative breast cancer, and ovarian cancer. An increased risk of Hodgkin lymphoma was observed only for women with naturally dark hair (based on 70 women, 24 with dark hair), and a higher risk of basal cell carcinoma was observed for women with naturally light hair.
Conclusion No positive association was found between personal use of permanent hair dye and risk of most cancers and cancer related mortality. The increased risk of basal cell carcinoma, breast cancer (estrogen receptor negative, progesterone receptor negative, hormone receptor negative) and ovarian cancer, and the mixed findings in analyses stratified by natural hair color warrant further investigation.
DOI: 10.1136/bmj.m2942
Source: https://www.bmj.com/content/370/bmj.m2942