REGN-COV2抗體能夠預防和治療恆河猴和倉鼠中的SARS-CoV-2感染
作者：
小柯機器人發布時間：2020/10/12 16:57:25
REGN-COV2抗體能夠預防和治療恆河猴和倉鼠中的SARS-CoV-2感染，這一成果由Regeneron製藥Christos A. Kyratsous團隊於近日取得。該研究於2020年10月9日在線發表於國際一流學術期刊《科學》。
研究人員之前報導了REGN-COV2，這是兩種有效的中和抗體（REGN10987+REGN10933）的混合物，其靶向SARS-CoV-2突刺蛋白上的不重疊表位。研究人員評估了該抗體混合物在恆河猴（可能模擬輕度疾病）和金色倉鼠（可能模擬更嚴重疾病）中的體內功效。
研究人員證明，當在恆河猴中進行預防性或治療性給藥時，REGN-COV-2可以大大降低下呼吸道和上呼吸道的病毒載量，並減少病毒引起的病理性皰疹。同樣，倉鼠給藥可限制體重減輕，並降低肺滴度和肺炎。這些結果表明，該抗體混合物具有治療潛力。
研究人員介紹，全球正在迫切尋求有效的療法來預防和治療COVID-19疾病。
附：英文原文
Title: REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters
Author: Alina Baum, Dharani Ajithdoss, Richard Copin, Anbo Zhou, Kathryn Lanza, Nicole Negron, Min Ni, Yi Wei, Kusha Mohammadi, Bret Musser, Gurinder S. Atwal, Adelekan Oyejide, Yenny Goez-Gazi, John Dutton, Elizabeth Clemmons, Hilary M. Staples, Carmen Bartley, Benjamin Klaffke, Kendra Alfson, Michal Gazi, Olga Gonzalez, Edward Dick, Ricardo Carrion, Laurent Pessaint, Maciel Porto, Anthony Cook, Renita Brown, Vaneesha Ali, Jack Greenhouse, Tammy Taylor, Hanne Andersen, Mark G. Lewis, Neil Stahl, Andrew J. Murphy, George D. Yancopoulos, Christos A. Kyratsous
Issue&Volume: 2020/10/09
Abstract: An urgent global quest for effective therapies to prevent and treat COVID-19 disease is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10933) targeting non-overlapping epitopes on the SARS-CoV-2 spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques, which may model mild disease, and golden hamsters, which may model more severe disease. We demonstrate that REGN-COV-2 can greatly reduce virus load in lower and upper airways and decrease virus induced pathological sequalae when administered prophylactically or therapeutically in rhesus macaques. Similarly, administration in hamsters limits weight loss and decreases lung titers and evidence of pneumonia in the lungs. Our results provide evidence of the therapeutic potential of this antibody cocktail.
DOI: 10.1126/science.abe2402
Source: https://science.sciencemag.org/content/early/2020/10/08/science.abe2402
Science：《科學》，創刊於1880年。隸屬於美國科學促進會，最新IF：41.037