Your doctor may obtain a liver biopsy (肝臟活檢) to determine the cause of liver disease and the extent of the damage. The liver is located in (位於) the upper right abdomen, just under the diaphragm (橫膈膜). It lies almost entirely within the ribcage (胸廓) which provides some protection to the organ. The liver is critical for digestion (消化) and metabolism (新陳代謝). Its many functions include producing bile which is necessary for fat absorption, producing proteins from amino acids (胺基酸), packaging fat for storage or transportation in the blood, regulating blood sugar levels (調節血糖) and processing substances such as alcohol and drugs. A liver biopsy may be ordered to determine the cause of abnormal liver function tests, swelling or enlargement of the liver, and jaundice (黃疸), the yellowish discoloration of the skin and white of the eye that develops when the serum bilirubin is elevated(血清膽紅素升高). Bilirubin is normally metabolized (代謝) by the liver. These signs and symptoms may be due to a variety of liver conditions including cirrhosis (肝硬化), hepatitis (肝炎) or cancer.
Before the procedure, IV line will be started and you may be given a sedative (鎮靜劑) to help you relax. A liver biopsy is done with local anesthesia (局部麻醉藥) so you will be awake during the procedure. You will be asked to lie on your back (平臥) with your right arm above your head. You will need to lie as still as possible during the procedure (術中儘量保持不動). The right lung and gallbladder are close to the liver and moving could cause damage to these organs. Your doctor will determine the location of your liver by ultrasound (超聲) or by lightly tapping your abdomen with his or her fingertips (用手指輕叩腹部). After cleaning the area over the biopsy site with an antiseptic(消毒劑). Your doctor will inject a local anesthetic to numb (麻醉) the skin and surface of the liver. Once the skin is numb, your doctor will make a small Nick with a surgical blade (用手術刀片切一小口). This is where the needle will be introduced. Your doctor will carefully advance the biopsy needle to the surface of the liver. Your doctor will then ask you to hold your breath (屏住呼吸)while he or she advances the needle into the liver and obtains the tissue sample (組織樣本).
As soon as the biopsy is obtained, you will be able to breathe normally. You may feel a momentary sensation (短暫的感覺) in your right shoulder during or just after the biopsy. Some patients have pain that requires additional medication which is provided by your doctor if needed. Afterward, pressure will be applied at the site of the biopsy to stop any bleeding (在活檢處採用壓迫止血) and a bandage will be placed on the incision. You will need to lie on your right side (右側臥位) for a minimum of one hour following the biopsy after the procedure. Your blood pressure and heart rate will be closely monitored after lying on your right side for an hour or two. You'll be asked to lie on your back for a minimum of three additional hours. Liver biopsies are considered outpatient procedures (門診手術) if there are no complications (併發症). You will be discharged four to eight hours after the procedure.
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