研究利器| OncoLnc:TGCA數據挖掘工具
oncoLnc是一個交互式工具可以探索生存相關性,下載臨床數據後,將其與mRNA,miRNA和lncRNA表達數據進行偶聯分析。
oncoLnc的網址:
http://www.oncolnc.org
oncoLnc包含的數據:
OncoLnc包含8647個病人的生存數據,它們來自TCGA的21種癌症研究,其中mRNA和miRNA來自TCGA的RNA-seq表達數據,lncRNA表達來自MiTranscriptome beta數據。分類數據能夠讓用戶能夠通過基因表達獲取病人信息,隨後製作Kaplan-Meier plots或者下載相應數據做進一步分析。
mRNAs: Use a modern HUGO gene symbol or Entrez ID
miRNAs: mature miRBase name or accession number
lncRNAs: MiTranscriptome Beta name or transcript ID
在 MiTranscriptome Beta 和TCGA Tier 3 data數據之間名字會有一些衝突
Rank(排名): Where the gene ranks by p-value compared to all other genes in that cancer study. mRNAs, miRNAs, lncRNAs are ranked separately.
Median expression(中位表達水平): Median expression of the gene. If a patient had more than one expression file they were averaged.
Mean expression(均值表達水平): Mean expression of the gene. If a patient had more than one expression file they were averaged.
Kaplan(生存分析圖): Go to an interactive Kaplan-Meier plotter
輸入搜索詞:neat1
繪製曲線
繪圖所使用的數據信息:
MiTranscriptome Beta:
Normalized expression was used and I believe they were normalized across cancers.
TCGA Tier 3 mRNAs:
Normalized expression was used. I do not know if it is safe to compare expression across cancers.
TCGA Tier 3 miRNAs:
Expression was not normalized across cancers, it is not recommended to compare across cancers.
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