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郵箱：cxw@med.tj.cn
微信：iamjade2016
院所：明斯特大學醫院 University Hospital of Muenster (UKM), WWU
部門：The Institute of Cell Biology
申請郵箱：Bewerbung@ukmuenster.de
截止日期：January 15, 2020
介紹
明斯特大學醫院是德國領先的醫院之一。如果僅憑規模和醫學上的成功是無法實現其現在這一地位。個人的貢獻也十分重要。我們需要您的付出，即使很小一部分，也可以為我們的患者帶來很多。有許多可能性供您選擇，以便您同時發展。
德國明斯特大學醫院細胞生物學研究所提供的職位初始任職時限為3年
——發育與細胞生物學博士生（gn）*
我們的實驗室研究了果蠅組織形態發生過程中微管細胞骨架組織和時空控制的時空動態。特別是，我們有興趣在系統層面了解細胞如何在細胞結構和集體細胞行為的不同方面調節和協調細胞骨架力。我們的研究依賴於將新的光學和化學工具與經典的遺傳方法和先進的圖像分析相結合，以定量分析細胞在形態發生組織重排和傷口癒合過程中如何協調細胞骨架力的動態變化，尤其著重於微管。
在這個項目中，我們將研究調節微管生物物理特性的分子機制。各個微管的特徵在很大程度上取決於（i）不同的α-和β-微管蛋白同工型的表達，以及（ii）各個微管蛋白單體的翻譯後修飾（PTM）。然而，儘管它們具有重要意義，但迄今為止尚未在體內解決不同微管蛋白同工型和PTM在細胞和組織力學中的作用。為了識別「機械」微管蛋白代碼，我們將分析微管蛋白同工型的表達模式，探討其在調節微管特性中的作用，研究非中心體微管的PTM，並測試當它們暴露於增加的機械作用下它們在細胞和組織重塑中的作用。
可以在這裡找到更多信息：https : //www.uni-muenster.de/Cells-in-Motion/de/people/all/matis-m.php
要求
申請
請於2020年1月15日前通過電子郵件將您的申請表與常規文件（研究動機/陳述，一份簡歷，一份出版物清單以及兩名推薦人的詳細信息）一起發送至Bewerbung@ukmuenster.de。
Job description
The University Hospital of Münster is one of the leading hospitals in Germany. Such a position cannot be achieved by size and medical successes alone. The individual commitment counts above all. We need your commitment so that even with little things we can achieve great things for our patients. There are many possibilities open for you so that you may develop with them.
The Institute of Cell Biology, University Hospital of Münster, Münster, Germany offers a position, initially limited to 3 years, of a PhD Student (gn) in Developmental and Cell Biology*
Ref. 04332
Part-Time with 65%
Salary according to TV-L E13
(*gn=gender neutral)
Our lab investigates the spatio-temporal dynamics of microtubule cytoskeleton organization and force control during tissue morphogenesis in Drosophila. In particular, we are interested in understanding at a systems level how cells regulate and coordinate cytoskeletal forces in different aspects of cell architecture and collective cell behavior. Our research relies on combining new optical and chemical tools in conjunction with classical genetic approaches and advanced image analysis to quantitatively analyze how cells coordinate cytoskeletal force dynamics during morphogenetic tissue rearrangements and wound healing with a particular focus on microtubules.
In this project, we will investigate the molecular mechanisms that regulate biophysical properties of microtubules. Features of individual microtubules largely differ depending on (i) expression of different α- and β-tubulin isoforms, and by (ii) post-translational modifications (PTMs) of individual tubulin monomers. However, despite their importance, the role of different tubulin isoforms and PTMs in cell and tissue mechanics has to date not been addressed in vivo. To identify the 「mechanical」 tubulin code, we will analyse the expression pattern of tubulin isoforms, address their role in regulating microtubules properties, study PTMs of non-centrosomal microtubules and test their role in cell and tissue remodeling when they are exposed to increased mechanical stress.
Additional information can be found here: https://www.uni-muenster.de/Cells-in-Motion/de/people/all/matis-m.php