The following article is for informational purposes only.
Xtreme Supplement Warehouse does not support or promote the sale, distribution or possession of anabolic steroids, SARMS or any type of prescription medication.
WHAT ARE SARMS?
SARMS stands for Selective Androgen Receptor Modulators. They are a class of therapeutic compounds that have little to no androgenic properties and are mostly PURE ANABOLIC compounds. The beauty of SARMs is they provide the medicial benefits of fighting muscle wasting diseases, bone deterioriation, hypergonadism, and even cancer WITHOUT the SIDE EFFECTS of pharma meds or anabolic steroids.
THE BENEFITS OF SARMS
SARMS have the capacity to employ the benefits of anabolic supplements while reducing the side effects of steroids.
SARMS are believed to have the capacity to employ the benefits of anabolic supplements while reducing the side effects of steroids.
· Non-toxic (won’t cause liver damage)
· Avoids bone loss (direct action of testosterone in bone thru the AR-mediated conduit is critical for its anabolic effects in bone)
· Decreases the threat of prostate problems in men without muscle mass loss
· Won’t impede your HPTA
· Similar effects with testosterone
· No estrogen and Dihydrotestosterone (a hydrogen hormone) conversion
For muscle builders, taking SARMS will give:
Muscle loss prevention (during cutting period)
Lean muscle development
Improved strength
Faster injury recovery
Joint healing abilities
PCT use following anabolics
WHAT DOES THE SCIENTIC RESEARCH SAY?
Increased muscle strength: In the Asian Journal ofAndrology, subjects increased muscle strength 20x more than those in the placebo group. Subjects continued to gain strength and size in muscle tissuefor up to 5 months but with significant decreases in effectiveness after the 3rd month (Dalton et al, 2014).
Increased muscle size: Deductive evidence has proven asignificant increase in muscle tissue hypertrophy (growth of muscle tissue).Inductive evidence suggests subjects will gain between 3 to 15 lbs of muscle tissue over the a 12 week period (Dubois et al, 2015). The amount of musclehypertrophy is dependent on diet, training, and the characteristics of theSARM. Mild SARMs such as MK 2866 will range much lower in hypertrophy than more potent SARMs such as RAD140 or LGD4033.
Tissue selectivity: According to the Oxford Academicjournal of Endocrinology, nonsteroidal SARMs have been designed to attachitself to area of the DNA responsible for skeletal muscle protein synthesis.Unlike other anabolic agents, non steroidal SARMs do not affect any other tissues in the body (Dubois et al, 2015).
Inhibits cancer cell division: In an unrelated study tomuscle growth performed by the Public Library of Science’s (PLOS) Peer Reviewed Open Access Journal, nonsteroidal SARMs have been studied for its effects onbreast cancer. Androgen receptors are known to play a pivotal role in the treatment of breast cancer and due to the inability for nonsteroidal SARMs to convert to estrogen, there is a very narrow probability for negative repercussions. The results have not only confirmed that tumor cells decrease inweight by 90%, but it may even inhibit the potential for breast cancerdevelopment (Dalton et al, 2014).
Regulation of libido: Recent study have indicated healthyincreases in sexual desire in both men and women with the use of nonsteroidalSARMs. The males with hypogonadism, testosterone therapy is a common practice.In testosterone therapy there are many side effects that result is severe consequences for the user, such as thickening of the blood (commonly causing strokes and heart attacks), enlargement or development of cancer on theprostate, and gynecomastia (characterized as the development of female breaston men) due to an overproduction of estrogen. A 2014 article published by the Asian Journal of Andrology stated 「SARM’s beneficial pharmacology and desirable pharmacokinetics offer considerable promise in the treatment of late onset hypogonadism. The convenience of once daily oral therapy combined with defined safety margins surrounding a proven efficacious dosage form may one day challenge testosterone replacement therapy as the gold standard in treatinglate onset hypogonadism」 (Dalton et al, 2014).
In the Journal of Pharmacology and Experimental Therapeutics, Researcher reported positive effects of nonsteroidal SARMs on females with low sexual motivation indicating noticeable increases insexual desire (Jones et al, 2010).
Safety and tolerability: In the Oxford Journal of Gerontology Series A: Biological Sciences and Medical Sciences, the popular nonsteroidal SARM LGD 4033 (Ligandrol) has been recently studied for it’s effectiveness and safety in healthy young men. Results were favorable indicatedby hormone and lipid levels returning to normal without the use of a post cycle therapy. No dangers were detected throughout the study. although there wasnoticeable suppression in testosterone and HDL cholesterol, it was not significant enough to cause adverse reactions. Because LGD 4033 is considered one of the strongest and most potent nonsteroidal SARMs available, it is notlikely that less potent SARMs will produce any harmful effects (Bhasin, 2010).
THE SIDE EFFECTS OF SARMS
The side effects from SARMS aremimimal as they are only slightly suppressive to your natural testosterone levels. With responsible use 99.9% of people will not experience gyno or testosterone shutdown.
S4 can cause vision side effectswhen going from a well lit place to a dark one. This side effect is onlytemporary and will go away after 2-3 days after using it.
When using RAD-140 a post cycle therapy is advised as it is the most potent and strongest SARM available.
SARMS VS ANABOLIC STEROIDS
SARMS have less side effects and therefore are weaker right? SARMS are SELECTIVE, steroids are not selective.SARMS have been compared to a bullet shot at a specific target compared to abomb (steroids) that will blow up everything in sight. Obviously steroids are extremely effective and will do the job in most cases but you have a number of possible side effects to think about.
As we age, our endurance, power and skeletal muscle mass deteriorates due to loss of type 2 muscle fibres. With SARMS, skeletal muscle mass and strength in androgen-deficient people will be enhanced.
There are two types of administering SARMS-orally or in injectable dosages. The anabolic effect is expected to be the SAME as TESTOSTERONE. Moreover, it is also said to produce dose-dependant improvements in bone mineral density and motorized strength apart from the ability to decreace body fat and increase lean body mass.
SARMS link to the same receptorsthat steroids such as Dianabol and TESTOSTERONE connect to, but minus the drawbacks and side effects of traditional steroids.
TYPES OF SARMS
MK-2866 OSTARINE
Ostarine, also known as MK-2866 is a SARM created to avoid and treat muscle wasting and hormone or testosterone replacement therapy. This SARM cannot only retain lean body mass but will also increase it.
BENEFITS OF OSTARINE
Increased lean mass gains
Better strength
More endurance
Joint healing abilities
Anabolic (even at doses as low as 3 mg)
Muscle retention during PCT/bridge between cycles
HOW OSTARINE WORKS
SARMS bind to the androgen receptor(AR) and shows osteo (bone) and myo (muscular) selective anabolic activity. The tying and stimulation intensifies protein synthesis and builds muscle.
Ostarine causes muscle growth just like steroids but it won’t produce negative side effects commonly found in anabolic steroids and prohormones such as prostate and other secondary sexual organs.
MK-2866 uses its anabolic effects on muscle tissue fully so it’s not only a potential for curing muscle wasting ailments but also it has great potential for muscle building for athletes,bodybuilders and fitness buffs. It is also an agent to reduce degeneration during recovery times from serious surgery or similar conditions.
Ostarine has undergone 8 scientifictrials by GTx with about 600 subjects plus 3 efficiency studies. A 4-monthPhase IIb medical trial including 159 patients have shown a complete boost in total lean muscle mass compared to placebo and the secondary goal of increasing muscle strength.
In terms of bodybuilding, Ostarineusers have proven that MK-2866 can help improve lean muscle mass and strength levels.
POSSIBLE SIDE EFFECTS OF OSTARINE
MK-2866 is fully side effect free.The only threat is that it’s possible to experience some mild natural test shutdown in cycles over 4 weeks, but the time between cycles (PCT) is only 4 weeks.
MK-677 NUTROBAL
MK 677 (Nutrobal) is similar topeptides like Ipamorelin and GHRP-6, but is administered orally and unlikely toset off the side effects that the latter can possibly cause during use. Apart from ease of use since you don’t have to do painful and inconvenient injections with MK 677 (Nutrobal), you can also expect to have significant changes in your IGF-1 and growth hormone levels while on the product.
BENEFITS OF NUTROBAL
Promotes the healing of ligaments, tendons, bones as well as old injuries
Stimulates loose skin to tighten
Promotes lean muscle mass
Increases the oxidation of fat
Increases growth hormone levels
POSSIBLE SIDE EFFECTS
Like other products that stimulate the elevated amounts of growth hormones in the body, MK677 (Nutrobal) can cause a slight increase in appetite, temporary bouts oflethargy and numb hands.
S4 ANDARINE
S4 (Andarine) or Acetamidoxolutamide, is said to be the most potent SARM which helps sustain lean muscle mass while stimulating fat elimination at the same time.
HOW S4 WORKS
S-4 attaches to the AR and sticks to it; each time the AR interacts with testosterone, S-4 forces it to produce genes that exclusively benefit muscleand bone growth. In other words, S4 is a form of SARM that attaches to theandrogen receptor (AR) the same with regular androgens, the only variation isthat S4 generates selective anabolic activity.
THE BENEFITS OF S4 OVER STEROIDS
Very minimal growth on secondary sexual organs such as the prostate.
The LDL/ HDL ratio is not affected which makes it a low cardiovascular risk.
0% chance of aromatization, male breast lactation, or rise in anyother female characteristic during the post cycle recovery.
Testosterone is not diminished in any capacity during the post cycle recovery.
Very exclusive in tissue selection and growth which means it will not cause heart enlargement or damage to neighboring organs.
SARMs do NOT require the utilization or devouring of liver enzymes to activate their anabolic effects. This eliminates any risk of hepatotoxicity or hepatitis.
Although SARMs such as S-4 are not as powerful as comparable steroids such as Winstrol, they do not require the extensive post cycle therapy and can be cycled back to back throughout the year. Over the course of a year, obtaining the same results is very possible.
SARMs is very female friendly and does not cause excessive masculine features such enlarged sexual characteristics.
S-4 has overall presented larger increases in muscle mass than DHT.
RAD 140
According to the Cambridge-basedpharmaceuticals company Radius, the potent, orally bioavailable and nonsteroidal RAD 140 SARM is designed to make the hormonal receptors in the tissues of the body act the same way as if they’re getting a good dose of testosterone, setting off the same effects as if you’re cycling with prohormones and anabolic steroids minus unwanted side effects.
BENEFITS OF RAD 140
Similiar to having an anabolic steroid and prohormone cycle, you’re going to have the following benefits whenyou use RAD 140 SARM:
Enhanced speed, stamina and endurance during high-intensity workouts
Faster buildup of muscular tissues that helps you achieve moregains in a shorter period of time
Based on medical tests, RAD 140SARM also displayed a greater anabolic effect than testosterone when used. Researchers pointed out that besides having a more 「reinforced」 effect than testosterone,RAD 140 SARM was also seen to help reduce the androgenic side effects that can be potentially caused by the same on the prostate.
This makes its usage way safer and more effective compared to traditional prohormones and anabolic steroids available commercially.
POSSIBLE SIDE EFFECTS OF RAD 140
Researchers point out that they still haven’t come across any adverse side effects that RAD 140 SARM can cause when used. However, a PCT would be advisable.
SARMS IN SPORTS
Athletes began dopimg with SARMS in the late 2000s. In the 2008 olympics it was estimated that over 80% of atheletes were using SARMS. Today they are of course banned. So athletes have to be very careful to time their use away from testing. One of the most recent incidents involved Florida quaterback Will Grier who was caught using LGD.
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