Nature :簡化的細胞分裂周期

細胞分裂過程需要一系列有序的事件來確保遺傳信息的正確複製及其準確分布。這種複製周期的調控非常複雜，使得了解其關鍵原理很困難。為了研究真核細胞有絲分裂周期的核心引擎，Damien Coudreuse 和 Paul Nurse在裂殖酵母中生成了一個高度簡化的最小控制網絡。基於用基因工程方法做成的單一CDK（依賴於細胞周期蛋白的激酶）振蕩器的這個體系，在沒有那些在能夠完全發揮功能的細胞中起作用的很多已知的調控性輸入和反饋存在的情況下，實現了細胞周期中主要事件的有序演進。（生物谷Bioon.com）

生物谷推薦原文出處：

Nature    doi:10.1038/nature09543

Driving the cell cycle with a minimal CDK control network

Damien Coudreuse& Paul Nurse

Control of eukaryotic cell proliferation involves an extended regulatory network, the complexity of which has made it difficult to understand the basic principles of the cell cycle. To investigate the core engine of the mitotic cycle we have generated a minimal control network in fission yeast that efficiently sustains cellular reproduction. Here we demonstrate that orderly progression through the major events of the cell cycle can be driven by oscillation of an engineered monomolecular cyclin-dependent protein kinase (CDK) module lacking much of the canonical regulation. We show further that the CDK oscillator acts as the primary organizer of the cell cycle, imposing timing and directionality to a system of two CDK activity thresholds that define independent cell cycle phases. We propose that this simple core architecture forms the basic control of the eukaryotic cell cycle.