姜雨,1983年生,男,二級教授,博士生導師
西北農林科技大學 動物科技學院 副院長
反芻動物遺傳與進化研究中心 主任
工作學習經歷:
2002-2006 復旦大學 生命科學院 理學學士;
2006-2011 中國科學院 昆明動物所 遺傳學博士;
2011-2013 澳大利亞聯邦科學院 家畜所 博士後;
2013-2015 西北農林科技大學 動物科技學院 副教授;
2015-至今西北農林科技大學 動物科技學院 教授;
姜雨
通過分子進化和群體遺傳學理論,分析農業領域在組學時代產生的海量數據,解析長期進化和人工選育過程中的關鍵農業性狀的主效基因及分子機制。特別關注反芻類家畜,其作為陸地上最主要的草食動物,研究其能高效利用不同生態地域飼草進行前胃發酵的遺傳成因,這對理解瘤胃菌群生態系統進化,通過仿生學研製人工瘤胃具有重要意義。
作為主要完成人之一,構建了世界上首個綿羊參考基因組和首個山羊參考基因組構建工作,並對世界主要肉羊品種的SNP和CNV 變異信息和頻率進行了系統整理分析,構建了家畜遺傳變異資料庫http://animal.nwsuaf.edu.cn/,並通過系統發掘功能位點標記,作為協調人以聯盟形式設計和定製了適用於中國綿羊和山羊的基因晶片,為羊的基因組選擇育種服務。
通過長期研究各種牛羊基因組變異與性狀關聯關係,解析出構成瘤胃壁的特異基因家族和反芻動物特有的脂類合成代謝途徑,部分解釋了瘤胃和羊毛脂產生的遺傳基礎,發表在2014年的《科學》雜誌。通過創新生物信息學分析方法,首次將光學圖譜用於基因組組裝和進行全基因組結構變異的關聯分析,2013年和2015年在《自然-生物技術》雜誌發表論文兩篇。在2019年從遺傳學角度首次提出牛羊鹿的角具有相同的細胞起源—頭部神經脊幹細胞,並發現鹿角利用了癌症通路和抑癌基因進行再生卻不癌化,為無角牛、羊的育種提供了理論基礎和關鍵靶基因,也為鹿角再生和癌症治療提供了新思路,以通訊作者發表在《科學》雜誌上。在2020年分別組裝出首個湖羊和西農薩能奶山羊的參考基因組,並解析了世界綿羊和山羊品種的遺傳來源,並在山羊上鑑定出關鍵的抗病基因 MUC6 ,發表在《科學-進展》和《分子生物進化》等雜誌。
到目前為止在國際學術期刊發表論文30餘篇,被引用1500餘次。在國際學術會議做大會報告或邀請報告14次,在國內學術會議上作報告50餘次。
校黨委常務副書記趙忠、副書記呂衛東和副校長陳玉林,向在國際頂級期刊《科學》發表論文姜雨教授及團隊祝賀
主持國家優秀青年科學基金項目「羊的基因組與分子育種」、面上項目和學校雙一流學科群PI團隊等科研項目。:
1、獲得2014年中國科學院「優秀博士學位論文獎」
2、入選2015年「國家青年人才計劃」項目
3、獲得2018年農業部「傑出青年農業科學家」稱號
4、獲得2019年雲南省「自然科學獎」一等獎(1/7)
姜雨教授和研究生們在工作。
1. Zheng Z#, Wang X#, Li M#, Li Y#, Yang Z#, Wang X#, …, Chen Y*, Jiang Y*.The origin of domestication genes in goats, Science Advances (2020)
2. Cai Y#, Fu W#, Cai Da#,..., Jiang Y*, Wang X*.Ancient genomes reveal the evolutionary history and origin of cashmere producing goats in China. Molecular Biology and Evolution (2020)
3. Wang Y, Zhang C, Wang N, ,…, Jiang Y*,Wang W*, Q Qiang*. Genetic basis of ruminant headgear and rapid antler regeneration. Science, 364, eaav6335(2019)
4. Chen L#, Qiu Q#, Jiang Y#,,…,Heller R*, Wang W*. Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits. Science , 364,eaav6202 (2019)
5. Chen N#, Cai Y#, Chen Q#,...,Jiang Y*, Lei C*. Whole-genome resequencing reveals world-wide ancestry and multiple adaptive introgression events of domesticated cattle in East Asia. Nature Communications , 9 (1), 2337(2018)
6. Zhou Z#, Li M#, Cheng H#,..., Hou S*, Jiang Y*. An intercross population study reveals genes associated with body size and plumage color in ducks. Nature Communications ,9,2648(2018)
7. Wang X, Zheng Z, Cai Y, Chen T, Li C, Fu W, Jiang Y*. CNVcaller: Highly Efficient and Widely Applicable Software for Detecting Copy Number Variations in Large Populations. GigaScience , 12.4, 6(12) (2017)
8. Jiang Y#, Xie M#, Chen W#…, Wang W*, Dalrymple B*. 2014. The sheep genome illuminates biology of the rumen and lipid metabolism. Science 344 (2014): 1168-1172.
9. Zhou Z#, Jiang Y#, Wang Z#…, Wang W*, Tian Z*. Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean. Nature biotechnology 23(4): 408-414 (2015)
10. Dong Y#, Xie M#, Jiang Y#…, Wang J*, Wang W*, Sequencing and automated whole-genome optical mapping of the genome of a domestic goat. Nature Biotechnology 31(2): 135-141 (2013)
1、Zheng Z, Wang X, Li M, Li Y, Yang Z, Wang X, …, Chen Y*, Jiang Y*.The origin of domestication genes in goats, Science Advances (2020)
2、Cai Y#, Fu W#, Cai Da#,..., Jiang Y*, Wang X*.Ancient genomes reveal the evolutionary history and origin of cashmere producing goats in China. Molecular biology and evolution (2020)
3、Jiao F#, Lou R#, Dai X#,Liu H#,…,Qian Y*, Zhao A*,Jiang Y*, Chromosome-level reference genome and population genomic analysis provide insight into the evolution and improvement of domesticated mulberry (Morus alba L), Molecular Plant (2020)
4、Sun T, Shen S, Achilli A,…,Jiang Y*, Lei C*.Genomic Analyses Reveal Distinct Genetic Architectures and Selective Pressures in Buffaloes. GigaScience . 2020 Feb 1;9(2):giz166.
5、Wang Y, Zhang C, Wang N, ,…, Jiang Y*,Wang W*, Q Qiang*. Genetic basis of ruminant headgear and rapid antler regeneration. Science, 364, eaav6335(2019)(cover story)
6、Chen L#, Qiu Q#, Jiang Y#, ,…,Heller R, Wang W. Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits. Science , 364,eaav6202 (2019) (cover story)
7、Tian X, Li R, Fu W, …, Li M*, Jiang Y*. Building a sequence map of the pig pan-genome from multiple de novo assemblies and Hi-C data. Science China Life Sciences (2019)
8、Chen H, Liu J, Wen J, …, Song W*, Sun Q*, Jiang Y* Frequent intra- and inter-species introgression shape the landscape of genetic variation in bread wheat. Genome Biology (2019)
9、Wang Y, Gao S, ZhaoY, …, Jiang Y*.Allele-specific expression and alternative splicing in horse×donkey and cattle×yak hybrids. Zoological Research (2019) (cover story)
10、Li C, Li M, Li X, , …, Jiang Y*,Hu S*. Whole-genome resequencing reveals loci associated with thoracic vertebrae number in sheep Frontiers in Genetics 2019
11、Cao Y, Xu H, Li R, …, Luo J*, Jiang Y*. Genetic Basis of Phenotypic Differences Between Chinese Yunling Black Goats and Nubian Goats Revealed by Allele-Specific Expression in Their F1 Hybrids. Frontiers in Genetics 10:145.doi: 10.3389/fgene.2019.00145
12、Chen N, Cai Y, Chen Q,...,Jiang Y*, Lei C*. Whole-genome resequencing reveals world-wide ancestry and multiple adaptive introgression events of domesticated cattle in East Asia. Nature communications , 9 (1), 2337(2018)
13、Zhou Z, Li M, Cheng H,..., Hou S*, Jiang Y*. An intercross population study reveals genes associated with body size and plumage color in ducks. Nature communications ,9,2648(2018)
14、Wang X, Liu J, Niu Y, ..., Huang X*, Jiang Y*, Chen Y*. Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep BMC Genomics (2018), 19:397
15、Wang X, Zheng Z, Cai Y, Chen T, Li C, Fu W, Jiang Y*. CNVcaller: Highly Efficient and Widely Applicable Software for Detecting Copy Number Variations in Large Populations. GigaScience , 12.4, 6(12) (2017)
16、Dong Y, Zhang X, Xie M, …, Wang W*, Jiang Y* Reference genome of wild goat and sequencing of goat breeds provide insight into genic basis of goat domestication. BMC Genomics (2015), 16:431
17、Chen H, Jiang Y*, Progress and Prospects in Domestic Animals and Breeding: a Review of Genomic Copy Number Variations. Biotechnology Bulletin (2015) 31(11): 35-42.
18、Li M, Zhou H, Pan X, …, Zi X*, Jiang Y*, Cassava foliage affects the microbial diversity of Chinese indigenous geese caecum using 16S rRNA sequencing[J]. Scientific Reports , 2017, 7.
19、Jiang Y#, Wang X#, Kijas J*, Dalrymple B*. Beta globin gene evolution in the ruminants: evidence for an ancient origin of sheep haplotype B. Animal Genetics (2015) 46:506–514
20、Zhou Z#, Jiang Y#, Wang Z#…, Wang W*, Tian Z*. Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean. Nature biotechnology 23(4): 408-414 (ESI Highly Cited Papers) (2015)
21、 Jiang Y#, Xie M#, Chen W#…, Wang W*, Dalrymple B*. 2014. The sheep genome illuminates biology of the rumen and lipid metabolism. Science 344: 1168-1172. (ESI Highly Cited Papers) (2014)
22、Dong Y#, Xie M#, Jiang Y#…, Wang J*, Wang W*, Sequencing and automated whole-genome optical mapping of the genome of a domestic goat. Nature Biotechnology 31(2): 135-141 (ESI Highly Cited Papers) (2013)
23、Jiang Y#, Li Y#, Lee W#, … ,Zhang Y*, Wang W*, Venom gland transcriptomes of two elapid snakes ( Bungarus multicinctus and Naja atra ) and evolution of toxin genes. BMC Genomics 12(1) (2011), 1-13.
24、Li D#, Dong Y#, Jiang Y#, … ,Wang W*, A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand. Cell Research 20(4),408-420. (2010)
1、 「The progress of sheep and goat genome assembly」 May 13-14, 2010, Shenzhen, China.
International Conference of 1000 Plant and Animal Reference Genomes Project
2、「Sequencing and assembly of the sheep reference genome」
Plant & Animal Genomes XIX Conference, Jan 15-19, 2011 San Diego, US.
3、「High-Resolution Analysis of Allelic Expression in Seven Sheep tissues」
Plant & Animal Genomes XIX Conference, Jan 15-19, 2011 San Diego, US.
4、「Sheep Genome Project: Gap Filling and Unbalanced Allelic Expression」
Plant & Animal Genomes XX Conference, Jan 14-18, 2012 San Diego, US.
5、「The quality of sheep reference genome, OAR v3.1」
5th 3SR Consortium Meeting, June 28-29, Alghero, Italy
6、「A reference genome of the domestic goat」
33rd International Society for Animal Genetics, July 15-20, 2012, Cairns, Australia
7、「The imprintome of a domestic sheep」
33rd International Society for Animal Genetics, July 15-20, 2012, Cairns, Australia
8、「The domestic sheep reference genome assembly」
33rd International Society for Animal Genetics, July 15-20, 2012, Cairns, Australia
9、「Detection of large-scale variation among sheep goat and cattle genomes」
34th International Society for Animal Genetics, July 27-31, 2014, Xi'an, China
10、「Comparative genomics analysis provides new insights to ruminant biology 」
9th International Conference on Genomics, Sep 9-12, 2014, Shenzhen, China
11、「Construction and evaluation of the Caprinae Pan-genome
3rd Livestock genomics meeting, Sep 14-16, 2016, Cambridge, UK
12、「The ruminant biology and evolution revealed by a flock of ruminant de novo genomes」
36th International Society for Animal Genetics, July 17-21, 2017, Dublin, Ireland
13、「world-wide ancestry and multiple adaptive introgression events of domesticated cattle」 Fossils and Ancient Genomics Symposium, Apr 17, 2018, Shenzhen, China
14、「Frequent intra- and inter-species introgression shape the landscape of genetic variation in bread wheat」 PAG ASIA 2019, Jun 6-8, 2019, Shenzhen, China