胼胝體（CC）是大腦中最大的白質結構，由2-2.5億對側大腦半球交叉過來的軸突組成。它是人類大腦半球主要的聯繫通路。胼胝體的病理學改變涵蓋了各種各樣的病因，包括先天、炎症、腫瘤、退變、感染等等。本研究回顧了在中樞神經系統脫髓鞘疾病中人類胼胝體最可靠的神經影像學數據，以促進對不同胼胝體病理學實體的認識，及其在可能的預後結果的評估作用。在對胼胝體的正常解剖和功能進行簡要描述後，本綜述審查了使用常規和功能性核磁共振成像獲得的最有價值的發現；還闡述了胼胝體特徵如何影響脫髓鞘疾病預後因素的最有序的發現，這對於選擇合適的治療方法具有很大的價值。另外，作者也簡要回顧了其他的非自身免疫性的病理因素引起的脫髓鞘疾病。總之，作者通過不同的影像學圖像展示了胼胝體作為大腦的重要一部分，對中樞神經系統脫髓鞘疾病的臨床評價，應該通過不同的成像方法來探討，以擴大我們對此類疾病的病理學和臨床模式的認識。
關鍵詞：胼胝體、中樞神經系統、脫髓鞘疾病、神經影像學、述評
Corpus callosum (CC) is the largest white matter structure in the brain, consisting of 200-250 million contralateral axonal projections. It is the major commissural pathway connecting the hemispheres of human brain. The pathology of CC includes wide variety of entities that arise from different causes such as congenital, inflammatory, tumoral, degenerative, infectious, etc. This study reviews the most reliable neuroimaging data of human CC in central nervous system (CNS) demyelinating diseases to facilitate the understanding of different pathological entities of the CC and their role in anticipation of probable prognostic findings. After a brief description of normal anatomy and functions of CC, this review examines the most valuable findings obtained using conventional and functional magnetic resonance imaging. It also demonstrates the most well organized findings of how CC features influence prognostic factors of demyelinating disorders, which could have a great value for choosing proper therapy methods. The authors also provided a brief review of other demyelinating disorders which are primarily caused by other pathological factors other than autoimmunity. As a conclusion, the authors showed the importance of CC as an critical part of the brain, which should be explored by different methods of imaging, correspondent to clinical evaluation of CNS demyelinating disorder to widen our knowledge on pathology and clinical patterns of such disorders.
Key words: Corpus callosum, central nervous system, demyelinating diseases, neuroimaging, review
各位讀者可複製此連結到瀏覽器中打開。
http://nnjournal.net/article/view/1887
或可點擊屏幕左下方「閱讀原文」，免費獲取全文！
Neuroimmunology and Neuroinflammation旨在報導神經免疫學與神經炎症最新研究進展，為該領域的研究學者和臨床醫生提供一個國際性學術交流平臺。自2014年6月創刊以來，期刊讀者遍布全球172個國家和地區，已在線發表文章161篇。誠摯歡迎您向我刊投稿，如有疑問，請郵件：nn_editor001@nnjournal.net。
中文摘要由編委，福建醫科大學、福建省立醫院神經內科陳興泳博士提供。中文內容僅供參考，一切以英文原版為準。
點擊掃描下圖二維碼，關注更多神經免疫與神經炎症的最新科研文章。一手資訊，輕鬆掌握！ 也可關注點擊掃描最下方圖片中的二維碼關注OAEChina公眾平臺，帶您了解最新醫學生物領域研究成果。
▼
-fin-