細胞培養相關文獻翻譯協作
自願
20世紀80年代重組哺乳動物細胞系建立以來，並且隨著分子生物學技術的不斷發展，細胞用於生物製品特別是疫苗的生產、檢測等方面越來越多。大腸桿菌、酵母、昆蟲細胞和哺乳動物細胞都可以用於蛋白的表達，但真核細胞較於原核表達系統，具有高質量的生物活性蛋白質，同時在操作及應用中可分為瞬時轉染短暫表達和穩定轉染持續表達。因此，在疫苗生產過程前，科研人員應結合病毒或細菌生物學及免疫學特性，克服真核細胞表達產量低、作業系統複雜等缺點，選擇合適的細胞系、培養基、培養條件和培養技術，以確保疫苗或其他生物製品在安全性和有效性的同時，還能保證經濟收益。現在適用於規模化培養的細胞包擴懸浮細胞、貼壁細胞核半貼壁細胞培養。有生物反應器、細胞工廠和微載體等等細胞培養技術。除了生產，與細胞相關製品的質量控制與保證，也是所有生物製品生產人員更關注的問題，這對於工藝設計、種子庫的來源和建立、工藝流程的確認和驗證、產品檢定方法的統一、人員培訓都有更加嚴格的要求。
因此，我們特搜集了關於疫苗及其他生物製品在細胞培養方面的文獻共33篇文獻，誠邀從事細胞培養或對其有興趣的您，貢獻您少量寶貴的業餘時間進行翻譯，便於同行資料信息的互通與交流。最終，我們會將譯文和原文全文分享，在此誠摯歡迎各同仁踴躍報名參與此次翻譯活動。
從事細胞培養以及對細胞培養感興趣的同仁
1.猛戳「閱讀原文」，填報個人信息進行預報名；
2.加微信號cbp510(可掃二維碼加入)，了解參與活動的相關規則；
3.通過翻譯測試稿進行篩選，根據翻譯的結果遴選參與人員；
4.拆分章節/段落，統一分發相關翻譯文件；
5.安排參與人員對翻譯作品進行相互校對；
6.完成後的譯本僅參與者共享；
7.對積極參與並按時完成的同仁，分享中文譯文全文。
1. A Consensus Genome-scale Reconstruction of chinese hamster ovary cell metabolism
2. A microneedle patch containing Mealse vaccine is immunogenic in non-human primate
3. A Novel Seed-Train Process using high-density cell banking a disposable bioreactor and perfusion technologies
4. Advanced Cell Culture Techniques for Cancer Drug Discovery
5. Advancement in bioprocess technology_ parallels between microbial natural products and cell culture biologics
6. Applicability of predictive toxicology methods for monoclonal antibody therapeutics status quo and scope
7. Assessment of packed bed bioreactor systems in the production of viral vaccine
8. Bioreactor concepts for cell culture-based viral vaccine production
9. Cell Culture for Production of Insecticidal Viruses
10. Cell culture processes for monoclonal antibody production
11. Cell substrates for the production of viral vaccines
12. CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion
13. Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the wave bioreactor
14. Current and Emerging Cell Culture Manufacturing technology for influenza vaccine
15. Designing cell lines for viral vaccine production_where do we stand
16. Engineering Cells to Improve Protein Expression
17. intensified Design of Experiments for upstream bioreactors
18. Lifecycle Management for Recombinant protein production using mammalian cell culture technology
19. Matrix and Backstage_ Cellular Substrates for Viral Vaccines
20. Micro-scaffold Array Chip for upgrading cell-based High-throughput drug testing to 3D using benchtop equipment
21. Model-based design of experiments for cellular process
22. Optimum Infection Conditions for Recombinant Protein Production in insect cell suspension culture
23. Overexpression of membrane proteins in mammalian cells for structural studies
24. Overexpression of YY1 increases the protein production in mammalian cells
25. Quality by controlTowards model predictive control of mammalian cell culture bioprocesses
26. Recombinant protein production from stable mammalian cell lines and pools
27. Scaled-up Manufacturing of Recombinant antibodies produces by plant cells in a 200L orbitally-shaken disposable bioreactor
28. Stable mammalian producer cell lines for structural biology
29. Three-Dimensional Cell Cultures in Drug discovery and development
30. Vaccines for the 21st century
31. vero cell platform in vaccine production moving towards cell culture-based viral vaccine
32. Viruses as vaccine vectors for infectious dieases and cancer
33. Comparison of Spectroscopy Technologies for Improved Monitoring of Cell Culyure Processes in Miniature Bioreactors.
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