Earlier detection is key to reducing cancer deaths. Here we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1,005 patients with non-metastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69% to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was > 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.
儘早查出是降低癌症死亡率的關鍵。本文介紹一種血液檢查，該血檢可以通過評估循環蛋白水平和游離DNA中的突變情況查出八種常見的癌症。我們對1005名病人分別進行了該項名為CancerSEEK的血液檢查，這1005名病人分別患有卵巢癌、肝癌、胃癌、胰腺癌、食道癌、結直腸癌、肺癌或乳腺癌。這八種癌症的血檢結果呈現陽性的中位值達70%。其中卵巢癌、肝癌、胃癌、胰腺癌和食道癌，這五種癌症對CancerSEEK的敏感度為69%到98%；並且，尚無可評估這五種癌症平均風險的檢查。CancerSEEK的特異性高於99%——在812名健康的對照組參與者中，只有7人的檢查結果呈陽性。此外，CancerSEEK可將患癌部位定位在少數解剖學位置，成功率的中位數為83%。