近日來自巴斯克地區大學（University of the Basque Country）的研究人員通過研究發現紫檀芪可以減少小鼠模型機體脂肪的堆積，其或許可以降低諸如糖尿病等疾病的風險，相關研究刊登於國際雜誌Journal of Agricultural and Food Chemistry上。
紫檀芪（Pterostilbene）是同白藜蘆醇同屬於一個家族的酚類化合物，其在多種食物中都存在但含量非常少；近日來自巴斯克地區大學（University of the Basque Country）的研究人員通過研究發現紫檀芪可以減少小鼠模型機體脂肪的堆積，其或許可以降低諸如糖尿病等疾病的風險，相關研究刊登於國際雜誌Journal of Agricultural and Food Chemistry上。
肥胖是由一系列因子影響的慢性疾病，其通常被定義為體內脂肪的過度堆積，肥胖也是發達國家非常流行的一種代謝性疾病，其也是引發其它疾病，比如高血壓、糖尿病等疾病的元兇。
傳統抑制及治療肥胖的準則包括低能量飲食及進行適量體力活動，然而這些策略的有效性非常有限，而且我們所認為的「成功」並沒有達到我們想要的結果；這項研究中，研究人員表示，一種飲食中有用的成分，即紫檀芪或許為治療肥胖提供了一定的希望。
紫檀芪是一種存在於許多食物和飲料中，含量非常少的化合物，目前對紫檀芪效應的研究非常少，而且研究者們主要進行其對癌症的效應研究；本文研究則是分析紫檀芪對肥胖小鼠模型的效應，在小鼠模型中，研究者發現紫檀芪可以切斷小鼠的機體脂肪，減少小鼠機體脂肪組織中脂肪的合成並且增加肝臟中氧化作用。研究者表示，未來研究中我們將進行人體實驗來評估紫檀芪的減肥效應，本文研究為後期我們開發抑制肥胖的新型療法提供了一定的幫助和希望。（轉化醫學網360zhyx.com）
https://www.360zhyx.com/home-research-index-rid-31845.shtml
（原文連結）
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轉化醫學網推薦的原文摘要：
Pterostilbene, a Dimethyl Ether Derivative of Resveratrol, Reduces Fat Accumulation in Rats Fed an Obesogenic Diet
J. Agric. Food Chem DOI: 10.1021/jf501318b
Saioa Gómez-Zorita †§, Alfredo Fernández-Quintela †§, Arrate Lasa †§, Leixuri Aguirre †§, Agnes M. Rimando #, and María P. Portillo *†§
The current study aimed to demonstrate the effects of pterostilbene in rats fed an obesogenic diet. For this purpose, pterostilbene was administered at doses of 15 mg/kg body weight/day (PT15 group) or 30 mg/kg body weight/day (PT30 group) for 6 weeks. Pterostilbene reduced adipose tissue mass −15.1% (PT15) and −22.9% (PT30). In this tissue, it decreased malic enzyme (−39.4 and −49.5% for PT15 and PT30 groups, respectively) and fatty acid synthase (−45 and −53.4% for PT15 and PT30) activities. Acetyl-CoA carboxylase activity was reduced and AMPK activity was increased only in the PT30 group. In the liver, pterostilbene (PT30) reduced malic enzyme (−29.5%) and glucose-6-P dehydrogenase (−43.2%) activities and increased carnitine palmitoyltransferase-1a (37.5%) and acyl-coenzyme A oxidase (42.5%) activities. This increased oxidative capacity was not associated with increased mitochondriogenesis. Among biochemical serum parameters, only insulin was modified by pterostilbene (−31.6%) in the PT15 group. The amounts of pterostilbene in serum and tissues from rats in the PT30 group were in not all cases 2-fold greater than those found in the PT15 group. In conclusion, pterostilbene shows antiobesity properties due, at least in part, to reduced lipogenesis in adipose tissue and increased fatty acid oxidation in liver.