TGFβ的競爭在表皮微環境中選擇性保留抗原特異性組織駐留記憶性T細胞
作者:
小柯機器人發布時間:2020/11/20 14:36:56
美國匹茲堡大學Daniel H. Kaplan、Toshiro Hirai等研究人員合作發現,TGFβ細胞因子的競爭在表皮微環境中選擇性保留抗原特異性組織駐留記憶性T細胞。2020年11月18日,《免疫》雜誌在線發表了這一研究成果。
研究人員發現,支持表皮駐留記憶T(Trm)細胞的轉化生長因子-β(TGFβ)來源是自分泌。此外,在皮膚中遇到同源抗原的抗原特異性Trm細胞和未在皮膚上遇到旁觀者的Trm細胞在穩態條件下均在表皮中顯示出長期持久性。但是,當TGFβ受到限制或將新的T細胞克隆募集到表皮中時,比旁觀者Trm細胞更有效地保留了抗原特異性Trm細胞。
在兩種情況下,遺傳強化的TGFβR信號使旁觀者Trm細胞像抗原特異性Trm細胞一樣有效地保留在表皮中。因此,T細胞之間對TGFβ的競爭是一種選擇性壓力,可促進抗原特異性Trm細胞在表皮微環境中的積累和持久性。
據介紹,淋巴結中抗原驅動的擴增發生之後,需要TGFβ才能將經皮膚招募的CD8+效應子T細胞分化為Trm細胞。
附:英文原文
Title: Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche
Author: Toshiro Hirai, Yi Yang, Yukari Zenke, Haiyue Li, Virendra K. Chaudhri, Jacinto S. De La Cruz Diaz, Paul Yifan Zhou, Breanna Anh-Thu Nguyen, Laurent Bartholin, Creg J. Workman, David W. Griggs, Dario A.A. Vignali, Harinder Singh, David Masopust, Daniel H. Kaplan
Issue&Volume: 2020-11-18
Abstract: Following antigen-driven expansion in lymph node, transforming growth factor-β (TGFβ)is required for differentiation of skin-recruited CD8+ T cell effectors into epidermal resident memory T (Trm) cells and their epidermalpersistence. We found that the source of TGFβ -supporting Trm cells was autocrine.In addition, antigen-specific Trm cells that encountered cognate antigen in the skin,and bystander Trm cells that did not, both displayed long-term persistence in theepidermis under steady-state conditions. However, when the active-TGFβ was limitedor when new T cell clones were recruited into the epidermis, antigen-specific Trmcells were more efficiently retained than bystander Trm cells. Genetically enforcedTGFβR signaling allowed bystander Trm cells to persist in the epidermis as efficientlyas antigen-specific Trm cells in both contexts. Thus, competition between T cellsfor active TGFβ represents an unappreciated selective pressure that promotes the accumulationand persistence of antigen-specific Trm cells in the epidermal niche.
DOI: 10.1016/j.immuni.2020.10.022
Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30463-5