ACS Applied Materials & Interfaces:石墨烯---還能治蛀牙

2015年3月13日 訊 /生物谷BIOON/ --牙科疾病是由於某些口腔細菌的生長而引起的，這是世界上最常見的健康問題。科學家們發現一種石墨烯氧化物材料可有效地消除這些細菌，這些細菌中的其中一些已經產生了抗生素耐藥性。這一發現發表在《ACS Applied Materials & Interfaces》。

Zisheng Tang和他的同事們通過研究發現，牙醫經常給病人開一些傳統抗生素以去除引起蛀牙和牙齦疾病的細菌。但是隨著抗生素耐藥性的增加，需要新的方法來解決這些問題，因為使用這些方法終會導致牙齒脫落。先前的研究已經表明，氧化石墨烯，石墨烯片存在於氧分子團中，這在生物醫學應用中是一種很有前途的材料。它可以抑制一些菌株的生長，但對哺乳動物細胞只有輕微傷害。Tang研究組想了解納米片是否會抑制口腔疾病中特定細菌的生長。

在實驗室中，研究人員測試了該材料對導致蛀牙和牙齦疾病的三個不同種類細菌的作用。通過破壞細菌細胞壁和細胞膜，石墨烯氧化物有效的抑制了病原菌的生長。研究人員因此得出結論，石墨烯片可能在牙科保健上有潛在的使用價值。

該項研究由上海自然科學基金和上海交通大學「醫工（理）交叉研究」提供資金支持。

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Killing Dental Pathogens Using Antibacterial Graphene Oxide

Jianliang He, Xiaodan Zhu, Zhengnan Qi, Chang Wang, Xiaojun Mao, Cailian Zhu, Zhiyan He, Mingyu Li, Zisheng Tang.

Dental diseases, which are caused by the overgrowth of certain bacteria in the mouth, are among the most common health problems in the world. Now scientists have discovered that a material called graphene oxide is effective at eliminating these bacteria, some of which have developed antibiotic resistance. They report the findings in the journal ACS Applied Materials & Interfaces. Zisheng Tang and colleagues point out that dentists often prescribe traditional antibiotics to get rid of bacteria that cause tooth decay or gum disease. But with the rise in antibiotic resistance, new approaches are needed to address these problems, which can lead to tooth loss. Previous studies have demonstrated that graphene oxide -- carbon nanosheets studded with oxygen groups -- is a promising material in biomedical applications. It can inhibit the growth of some bacterial strains with minimal harm to mammalian cells. Tang's team wanted to see if the nanosheets would also stop the specific bacteria that cause dental diseases.