部分難治性癲癇患者需要手術治療或放射治療，而致癇灶的定位是手術或伽瑪刀治療難治性癲癇的前提。一項關於「Gamma knife treatment for refractory epilepsy in seizure focus localized by positron emission tomography/CT」的研究以18F-氟代脫氧葡萄糖正電子發射型計算機斷層顯像/CT方法定位難治性癲癇患者，成功辨別60%的病灶，且對於高代謝灶和單病灶癲癇患者的定位更為準確。作者認為，18F-氟代脫氧葡萄糖正電子發射型計算機斷層顯像/CT方法可無創定位難治性癲癇病灶，可提高診斷的陽性率和準確率，同時能較為準確的評價癲癇的治療效果。此項研究成果發表在《中國神經再生研究（英文版）》2012年12月36期出版的雜誌上。(生物谷Bioon.com)
Gamma knife treatment for refractory epilepsy in seizure focus localized by positron emission tomography/CT
Xia Bai1, Xuemei Wang1, Hongwei Wang2, Shigang Zhao3, Xiaodong Han4, Linjun Hao5, Xiangcheng Wang1
A total of 80 patients with refractory epilepsy were recruited from the Inner Mongolia Medical College Affiliated Hospital. The foci of 60% of the patients could be positioned using a combined positron emission tomography/CT imaging modality. Hyper- and hypometabolism foci were examined as part of this study. Patients who had abnormal metabolism in positron emission tomography/CT imaging were divided into intermittent-phase group and the seizure-phase group. The intermittent-phase group was further divided into a single-focus group and a multiple-foci group according to the number of seizure foci detected by imaging. Following gamma knife treatment, seizure frequency was significantly lower in the intermittent-phase group and the seizure-phase group. Wieser’s classification reached Grade I or II in nearly 40% of patients. Seizure frequency was significantly lower following treatment, but Wieser’s classification score was significantly higher in the seizure-phase group compared with the intermittent-phase group. Seizure frequency was significantly lower following treatment in the single-focus group, but Wieser’s classification score was significantly higher in the single-focus group as compared with the multiple-foci group.