（英文原文）Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers
Aims While excessive sitting time is related adversely to cardio-metabolic health, it is unknown whether standing is a suitable replacement activity or whether ambulatory movement is required. Using isotemporal substitution analyses, we modelled cross-sectional associations with cardio-metabolic risk biomarkers of reallocating time (2 h/day) from sitting to standing or to stepping.
Methods and results A subsample of participants from the 2011/12 Australian Diabetes, Obesity, and Lifestyle Study wore the posture-based activPAL3 monitor [36–80 years (mean 57.9, SD 9.9 years); 57% women; n = 698 with data]. Associations of activPAL3-derived mean daily time sitting/lying (sitting), standing and stepping with body mass index (BMI), waist circumference, blood pressure, HbA1c, fasting glucose and lipids (high-density lipoprotein-, HDL, and low-density lipoprotein-cholesterol, total/HDL-cholesterol ratio, and triglycerides), and 2-h plasma glucose were examined. Adjusted for relevant confounders, sitting-to-standing reallocations were only significantly (P < 0.05) associated with approximately 2% lower fasting plasma glucose, 11% lower triglycerides, 6% lower total/HDL-cholesterol ratio, and 0.06 mmol/L higher HDL-cholesterol per 2 h/day. Sitting-to-stepping reallocations were only significantly associated with approximately 11% lower BMI, 7.5 cm lower waist circumference, 11% lower 2-h plasma glucose, 14% lower triglycerides, and 0.10 mmol/L higher HDL-cholesterol per 2 h/ day, while standing-to-stepping reallocations were only significantly associated with ∼10% lower BMI, 7 cm lower waist circumference, and 11% lower 2-h plasma glucose.
Conclusion Findings suggested that sitting-reduction strategies targeting increased standing, stepping, or both, may benefit cardio-metabolic health. Standing is a simple alternative to sitting, and requires further examination in prospective and intervention studies.
來源：ACC CV News Digest（August 1，2015）
【203】少坐多站/走或有益心臟健康（中文摘要）
近日一項研究結果顯示，少坐、多站和/或多走策略或有益於心臟代謝健康。站是坐的一種簡單替換，但人們還需要在前瞻性和幹預性研究中就此結論進行進一步驗證。
儘管坐的時間太久與心臟代謝健康負相關，但人們還不知道站立是否適合替代坐著，或者是否需要經常走動。本研究採用等時替代分析，建立重新安排坐、站或行走的時間（2小時/天）與心臟代謝危險標誌物相關性的橫斷面研究模型。來自澳大利亞糖尿病、肥胖症和生活方式研究的子樣本受試者（平均57.9歲，女性佔57%，其中698人有可用數據）佩戴了activPAL3姿勢監測儀。研究者檢驗了佩戴監測儀患者的每日平均坐/躺、站立和步行的時間與BMI、腰圍、血壓、HbA1c、空腹血糖、血脂（HDL-C、LDL-C、總膽固醇/HDL-C比值和甘油三酯）以及餐後2小時血糖之間的相關性。
結果顯示，在校正了相關的混雜因素後，每日重新安排坐-站時間2小時與空腹血糖下降約2%、甘油三酯下降11%、總膽固醇/HDL-C比值下降6%以及HDL-C增高0.06 mmol/L顯著相關（P<0.05）。每日重新安排坐-走時間2小時與BMI下降約11%、腰圍縮小7.5 cm、餐後2小時血糖下降11%、甘油三酯下降14%以及HDL-C增高0.10 mmol/L顯著相關，而每日重新安排站-走時間2小時僅與BMI下降約10%、腰圍縮小7 cm以及餐後2小時血糖下降11%顯著相關。
第26屆長城會將於2015年10月29日-11月1日北京·國家會議中心盛大召開，註冊會議請登錄長城會官網：www.gw-icc.org