多組學研究解析輕度和中度COVID-19之間的急劇變化
作者：
小柯機器人發布時間：2020/10/31 21:19:06
2020年10月28日，《細胞》雜誌在線發表了美國科學家的一項最新研究成果。來自華盛頓大學的James R. Heath、Jason D. Goldman等研究人員合作利用多組學解析了輕度和中度COVID-19之間的急劇變化狀態。
研究人員對139例COVID-19患者的臨床檢測、免疫細胞和血漿多組學進行了綜合分析，這些患者代表了疾病嚴重程度的所有水平，這些數據來自於診斷後感染後第一周的連續抽血。研究人員確定了輕度和中度疾病之間的主要轉變，在這一點上，炎症信號的升高伴隨著特定類別的代謝產物和代謝過程的喪失。在這種處於中等疾病的壓力血漿環境中，多種異常的免疫細胞表型出現並隨著疾病嚴重程度的增加而放大。
研究人員將超過120,000個免疫特徵濃縮到一個軸中，用於捕獲不同免疫細胞類別如何響應SARS-CoV-2進行協調。該免疫應答軸獨立地與主要血漿成分變化、血液凝結的臨床指標以及輕度和中度疾病之間的急劇轉變保持一致。這項研究表明，中度疾病可能為治療幹預提供最有效的環境。
附：英文原文
Title: Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19
Author: Yapeng Su, Daniel Chen, Dan Yuan, Christopher Lausted, Jongchan Choi, Chengzhen L. Dai, Valentin Voillet, Venkata R. Duvvuri, Kelsey Scherler, Pamela Troisch, Priyanka Baloni, Guangrong Qin, Brett Smith, Sergey A. Kornilov, Clifford Rostomily, Alex Xu, Jing Li, Shen Dong, Alissa Rothchild, Jing Zhou, Kim Murray, Rick Edmark, Sunga Hong, John Heath, John Earls, Rongyu Zhang, Jingyi Xie, Sarah Li, Ryan Roper, Lesley Jones, Yong Zhou, Lee Rowen, Rachel Liu, Sean Mackay, D. Shane OMahony, Christopher R. Dale, Julie A. Wallick, Heather A. Algren, Zager A. Michael, Wei Wei, Nathan D. Price, Sui Huang, Naeha Subramanian, Kai Wang, Andrew T. Magis, Jennifer Hadlock, Leroy Hood, Alan Aderem, Jeffrey A. Bluestone, Lewis L. Lanier, Philip D. Greenberg, Raphael Gottardo, Mark M. Davis, Jason D. Goldman, James R. Heath
Issue&Volume: 2020-10-28
Abstract: We present an integrated analysis of the clinical measurements, immune cells and plasma multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial blood draws collected during the first week of infection following diagnosis. We identify a major shift between mild and moderate disease, at which point elevated inflammatory signaling is accompanied by the loss of specific classes of metabolites and metabolic processes. Within this stressed plasma environment at moderate disease, multiple unusual immune cell phenotypes emerge and amplify with increasing disease severity. We condensed over 120,000 immune features into a single axis to capture how different immune cell classes coordinate in response to SARS-CoV-2. This immune-response axis independently aligns with the major plasma composition changes, with clinical metrics of blood clotting, and with the sharp transition between mild and moderate disease. This study suggests that moderate disease may provide the most effective setting for therapeutic intervention.
DOI: 10.1016/j.cell.2020.10.037
Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31444-6
Cell：《細胞》，創刊於1974年。隸屬於細胞出版社，最新IF：36.216