專題:Science報導
本次發表的《科學》文章主要解釋了Bcl6轉錄因子對輔助T細胞生長發育的調控作用。
CD4+輔助T細胞的一個基本功能是調節B細胞介導的體液免疫。濾泡輔助性T細胞(T follicular helper ,Tfh)通過細胞因子白介素-6和白介素-21來調節B細胞的功能。在Tfh發揮調節功能的過程中,Bcl6轉錄因子發揮了重要的作用。
Bcl6轉錄因子的表達受白介素-6和白介素-21的調控,Bcl6過度表達可誘導Tfh相關的基因表達並抑制其他類型的輔助性T細胞的分化。如果Bcl6缺陷則導致Tfh發育異常,並破壞生發中心的免疫應答,改變其他效應T細胞的表達量。
這些研究結果表明,Bcl6是Tfh細胞發育過程中必不可少的調節因子。(生物谷Bioon.com)
生物谷推薦原始出處:
Science DOI: 10.1126/science.1176676
Bcl6 Mediates the Development of T Follicular Helper Cells
Roza I. Nurieva 1*, Yeonseok Chung 1, Gustavo J. Martinez 1, Xuexian O. Yang 1, Shinya Tanaka 1, Tatyana D. Matskevitch 1, Yi-Hong Wang 1, Chen Dong 1*
1 Department of Immunology, M. D. Anderson Cancer Center, Houston, TX 77030, USA.
A fundamental function of CD4+ helper T (Th) cells is the regulation of B cell–mediated humoral immunity. Development of T follicular helper (Tfh) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21, but is independent of Th1, Th2, and Th17 effector cell lineages. Here, we characterize the function of Bcl6, a transcription factor selectively expressed in Tfh cells. Bcl6 expression is regulated by interleukin-6 and interleukin-21. Bcl6 overexpression induced Tfh-related gene expression and inhibited other Th lineage cell differentiation in a DNA binding–dependent manner. Moreover, Bcl6 deficiency in T cells resulted in impaired Tfh cell development, and germinal center reactions, and altered production of other effector T cells subsets. Our data thus illustrate that Bcl6 is required for programming of Tfh cell generation.