科學家發現在果蠅中調控攻擊行為的神經迴路
作者：
小柯機器人發布時間：2020/12/31 13:20:53
美國加州理工學院David J. Anderson研究小組揭示出在果蠅中調控攻擊行為的神經迴路。這一研究成果於2020年12月30日在線發表在國際學術期刊《細胞》上。
研究人員確定了三種調節果蠅攻擊性的細胞類型：一種是性別共享的，另一種是性別特異性的。共享的共同攻擊促進（CAP）神經元在兩性中介導攻擊行為，而功能下遊的雙態但同源的細胞類型（雄性中稱為雄性特異性攻擊性（MAP）神經元和雌性中的fpC1）控制雙態攻擊。這些對稱迴路是雄性和雌性的攻擊行為從單態飲食/動機階段到雙態完善階段的基礎。兩性之間的社會隔離增強了單態→雙態功能連接的強度，這表明它可能是隔離依賴性增強攻擊的一個因素。
總之，這些發現揭示了一種對行為進行神經控制的迴路邏輯，其中包括性單態和雙態行為，這些行為可能會推廣到其他生物。
據了解，攻擊性涉及性單態和雙態行為。人們對大腦如何實現這兩種類型的行為知之甚少。
附：英文原文
Title: A circuit logic for sexually shared and dimorphic aggressive behaviors in Drosophila
Author: Hui Chiu, Eric D. Hoopfer, Maeve L. Coughlan, David J. Anderson
Issue&Volume: 2020-12-30
Abstract: Aggression involves both sexually monomorphic and dimorphic actions. How the brainimplements these two types of actions is poorly understood. We have identified threecell types that regulate aggression in Drosophila: one type is sexually shared, and the other two are sex specific. Shared common aggression-promoting(CAP) neurons mediate aggressive approach in both sexes, whereas functionally downstreamdimorphic but homologous cell types, called male-specific aggression-promoting (MAP)neurons in males and fpC1 in females, control dimorphic attack. These symmetric circuitsunderlie the divergence of male and female aggressive behaviors, from their monomorphicappetitive/motivational to their dimorphic consummatory phases. The strength of themonomorphic → dimorphic functional connection is increased by social isolation inboth sexes, suggesting that it may be a locus for isolation-dependent enhancementof aggression. Together, these findings reveal a circuit logic for the neural controlof behaviors that include both sexually monomorphic and dimorphic actions, which maygeneralize to other organisms.
DOI: 10.1016/j.cell.2020.11.048
Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31620-2
Cell：《細胞》，創刊於1974年。隸屬於細胞出版社，最新IF：36.216