Nutrients. 2015 Feb 16;7(2):1301-17. doi: 10.3390/nu7021301.
Association of polyphenols from oranges and apples with specific intestinal microorganisms insystemic lupus erythematosus patients.
Our group has recently shown the existence of a gut microbial dysbiosis in systemic lupus erythematosus (SLE), supporting previous evidence involving intestinal bacteria in the initiation and amplification of autoimmune diseases. While several studies have addressed the use of dietary fibres to modify intestinal microbiota, information about other correlated components, such as polyphenols, is scarce. The aim of this work was to identify dietary components able to influence this altered microbiota in 20 SLE women and 20 age-matched controls. Food intake was recorded by means of a food frequency questionnaire. The intake of fibres was calculated from Marlett tables, and Phenol-Explorer was used for polyphenol consumption. Results showed positive associations between flavone intake and Blautia, flavanones and Lactobacillus, and dihydrochalcones and Bifidobacterium in the SLE group. Regarding the controls, dihydroflavonols were directly associated with Faecalibacterium, whereas flavonol intake was inversely associated with Bifidobacterium. From the food sources of these polyphenols related to microbiota, orange intake was directly associated with Lactobacillus and apple with Bifidobacterium in SLE, whilst red wine was the best contributor to Faecalibacterium variation. The association between common foods and particular microbial genera, reported to be decreased in SLE, could be of great importance for these patients.
我們的小組最近在系統性紅斑狼瘡（SLE）中顯示出腸道微生物生態系統的存在，支持以前在腸道細菌中引發和擴大自身免疫性疾病的證據。雖然幾項研究已經討論了使用膳食纖維來改變腸道微生物群，但是關於其他相關成分（例如多酚）的信息很少。這項工作的目的是確定能夠影響20名SLE女性和20名年齡匹配對照中這種改變的微生物群的飲食成分。通過食物頻率問卷記錄攝入食物。 纖維攝入量由Marlett表計算，苯酚探針用於多酚消費。結果顯示，SLE組中，黃酮攝入量與Blautia、黃酮酮和乳酸桿菌、二氫查耳酮和雙歧桿菌分別呈正相關。關於對照，二氫黃酮醇與糞便桿菌直接相關，而黃酮醇攝入與雙歧桿菌反相關。從與微生物群相關的這些多酚的食物來源中，橘子攝入與乳酸桿菌直接相關，蘋果與雙歧桿菌直接相關，而紅葡萄酒是對變形桿菌變異的最佳貢獻者。普通食物和特定微生物屬之間的關聯，據報導在SLE中降低，可能對這些患者非常重要。